biostudies-literatureMou Jthe Sichuan Science and Technology ProgramChina Postdoctoral Science FoundationSichuan Provincial Health and Family Planning CommissionChengdu University of Traditional Chinese MedicineYibin Science and Technology Bureaukkad014https://www.ebi.ac.uk/biostudies/studies/S-EPMC10939343biostudies-literatureUnknown3<h4>Background</h4>Major depressive disorder (MDD) has different clinical presentations in males and females. However, the neuroanatomical mechanisms underlying these sex differences are not fully understood.<h4>Objective</h4>The purpose of present study was to explore the sex differences in brain cortical thickness (CT) and surface area (SA) of MDD and the relationship between these differences and clinical manifestations in different gender.<h4>Methods</h4>High-resolution T1-weighted images were acquired from 61 patients with MDD and 61 healthy controls (36 females and 25 males, both). The sex differences in CT and SA were obtained using the FreeSurfer software and compared between every two groups by <i>post hoc</i> test. Spearman correlation analysis was also performed to explore the rPsychoradiologySex differences of brain cortical structure in major depressive disorder.PMC109393432015SF0302015M5825542020YW085SCU-HM-20210011502512018JY0666YYZX2020111Yang HMei LGong QLong ZGuo XMou JWang YZheng TYuan YQiu LfalseSex differences of brain cortical structure in major depressive disorder.<h4>Background</h4>Major depressive disorder (MDD) has different clinical presentations in males and females. However, the neuroanatomical mechanisms underlying these sex differences are not fully understood.<h4>Objective</h4>The purpose of present study was to explore the sex differences in brain cortical thickness (CT) and surface area (SA) of MDD and the relationship between these differences and clinical manifestations in different gender.<h4>Methods</h4>High-resolution T1-weighted images were acquired from 61 patients with MDD and 61 healthy controls (36 females and 25 males, both). The sex differences in CT and SA were obtained using the FreeSurfer software and compared between every two groups by <i>post hoc</i> test. Spearman correlation analysis was also performed to explore the r2023-01-01T00:00:00Z20232026-07-16T00:19:09.734Z2026-07-09T10:26:15.958ZS-EPMC109393433866613010.1093/psyrad/kkad014