{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zachry JE"],"funding":["NCATS NIH HHS","NICHD NIH HHS","NIDA NIH HHS","NIMH NIH HHS","NIAAA NIH HHS","NIGMS NIH HHS"],"pagination":["835-849.e7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10939818"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(5)"],"pubmed_abstract":["At the core of value-based learning is the nucleus accumbens (NAc). D1- and D2-receptor-containing medium spiny neurons (MSNs) in the NAc core are hypothesized to have opposing valence-based roles in behavior. Using optical imaging and manipulation approaches in mice, we show that neither D1 nor D2 MSNs signal valence. D1 MSN responses were evoked by stimuli regardless of valence or contingency. D2 MSNs were evoked by both cues and outcomes, were dynamically changed with learning, and tracked valence-free prediction error at the population and individual neuron level. Finally, D2 MSN responses to cues were necessary for associative learning. Thus, D1 and D2 MSNs work in tandem, rather than in opposition, by signaling specific properties of stimuli to control learning."],"journal":["Neuron"],"pubmed_title":["D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning."],"pmcid":["PMC10939818"],"funding_grant_id":["T32 GM007628","KL2 TR002245","R01 DA052317","R00 DA042111","R01 AA030931","DP1 DA048931","P50 HD103537","T32 MH065215","R21 MH132052","T32 MH135853"],"pubmed_authors":["Cai DJ","Thibeault KC","Conn PJ","Leonard MZ","Bethi R","Kutlu MG","Yoon HJ","Gaidici A","Kondev V","Calipari ES","Grueter BA","Zachry JE","Isiktas AU","Patel DD","Melugin PR","Tat J","Joffe ME","Chevee M"],"additional_accession":[]},"is_claimable":false,"name":"D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning.","description":"At the core of value-based learning is the nucleus accumbens (NAc). D1- and D2-receptor-containing medium spiny neurons (MSNs) in the NAc core are hypothesized to have opposing valence-based roles in behavior. Using optical imaging and manipulation approaches in mice, we show that neither D1 nor D2 MSNs signal valence. D1 MSN responses were evoked by stimuli regardless of valence or contingency. D2 MSNs were evoked by both cues and outcomes, were dynamically changed with learning, and tracked valence-free prediction error at the population and individual neuron level. Finally, D2 MSN responses to cues were necessary for associative learning. Thus, D1 and D2 MSNs work in tandem, rather than in opposition, by signaling specific properties of stimuli to control learning.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T09:10:14.955Z","creation":"2025-04-04T09:10:14.955Z"},"accession":"S-EPMC10939818","cross_references":{"pubmed":["38134921"],"doi":["10.1016/j.neuron.2023.11.023"]}}