{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie L"],"funding":["This work was supported by National Institute on Minority Health and Health Disparities","NIMHD NIH HHS"],"pagination":["368-376"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10939864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(4)"],"pubmed_abstract":["<h4>Background</h4>The association of asthma and metabolic syndrome (MetS) among adolescents and young adults (AYAs) remains unclear, as well as the role of obesity in this relationship.<h4>Methods</h4>AYAs aged 12-25 years who participated in the 2011-2020 National Health and Nutrition Examination Survey were included in this cross-sectional analysis. The moderating effect of obesity (age- and sex-adjusted body mass index ≥ 95th%ile for adolescents or ≥ 30 kg/m<sup>2</sup> for adults) on asthma and MetS were evaluated in four groups: 1) both asthma and obesity; 2) asthma and no obesity; 3) obesity and no asthma; and 4) healthy controls with no obesity/asthma.<h4>Results</h4>A total of 7,709 AYAs (53.9% aged 12-18 years, 51.1% males, and 54.4% non-Hispanic White) were included in this analysis. 3.6% (95% CI 2.8-4.3%) had obesity and asthma, 7.6% (95% CI 6.8-8.4%) had asthma and no obesity, 21.4% (95% CI 19.6-23.2%) had obesity and no asthma, and 67.4% (95% CI 65.4-69.4%) had neither obesity nor asthma. The estimated prevalence of MetS was greater among those with both obesity and asthma versus those with only asthma (4.5% [95% CI 1.7-7.3%] vs. 0.2% [95% CI 0-0.5%], <i>p</i> < 0.001). Compared to healthy controls, those with both obesity and asthma had ∼10 times higher odds of having MetS (aOR 10.5, 95% CI 3.9-28.1).<h4>Conclusions</h4>Our results show the association between MetS and asthma is stronger in AYAs with BMI-defined obesity. Efforts to prevent and treat obesity may reduce MetS occurrence in AYAs with asthma."],"journal":["The Journal of asthma : official journal of the Association for the Care of Asthma"],"pubmed_title":["Association between asthma, obesity, and metabolic syndrome in adolescents and young adults."],"pmcid":["PMC10939864"],"funding_grant_id":["R01 MD011686"],"pubmed_authors":["Afolabi F","Chandrasekhar A","Messiah SE","Ernest D","Martinez Fernandez T","Xie L","Gelfand A","Patel J","Almandoz JP"],"additional_accession":[]},"is_claimable":false,"name":"Association between asthma, obesity, and metabolic syndrome in adolescents and young adults.","description":"<h4>Background</h4>The association of asthma and metabolic syndrome (MetS) among adolescents and young adults (AYAs) remains unclear, as well as the role of obesity in this relationship.<h4>Methods</h4>AYAs aged 12-25 years who participated in the 2011-2020 National Health and Nutrition Examination Survey were included in this cross-sectional analysis. The moderating effect of obesity (age- and sex-adjusted body mass index ≥ 95th%ile for adolescents or ≥ 30 kg/m<sup>2</sup> for adults) on asthma and MetS were evaluated in four groups: 1) both asthma and obesity; 2) asthma and no obesity; 3) obesity and no asthma; and 4) healthy controls with no obesity/asthma.<h4>Results</h4>A total of 7,709 AYAs (53.9% aged 12-18 years, 51.1% males, and 54.4% non-Hispanic White) were included in this analysis. 3.6% (95% CI 2.8-4.3%) had obesity and asthma, 7.6% (95% CI 6.8-8.4%) had asthma and no obesity, 21.4% (95% CI 19.6-23.2%) had obesity and no asthma, and 67.4% (95% CI 65.4-69.4%) had neither obesity nor asthma. The estimated prevalence of MetS was greater among those with both obesity and asthma versus those with only asthma (4.5% [95% CI 1.7-7.3%] vs. 0.2% [95% CI 0-0.5%], <i>p</i> < 0.001). Compared to healthy controls, those with both obesity and asthma had ∼10 times higher odds of having MetS (aOR 10.5, 95% CI 3.9-28.1).<h4>Conclusions</h4>Our results show the association between MetS and asthma is stronger in AYAs with BMI-defined obesity. Efforts to prevent and treat obesity may reduce MetS occurrence in AYAs with asthma.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-06T16:44:35.689Z","creation":"2025-07-04T03:05:48.678Z"},"accession":"S-EPMC10939864","cross_references":{"pubmed":["37930803"],"doi":["10.1080/02770903.2023.2280763"]}}