biostudies-literatureClay SNCATS NIH HHSNCRR NIH HHSNIDDK NIH HHSNIAID NIH HHSNIEHS NIH HHSNHLBI NIH HHSNCI NIH HHSUS Department of DefenseNIHNIH HHSNIGMS NIH HHS809-820https://www.ebi.ac.uk/biostudies/studies/S-EPMC10939893biostudies-literatureUnknown153(3)<h4>Background</h4>Most genetic studies of asthma and allergy have focused on common variation in individuals primarily of European ancestry. Studying the role of rare variation in quantitative phenotypes and in asthma phenotypes in populations of diverse ancestries can provide additional, important insights into the development of these traits.<h4>Objective</h4>We sought to examine the contribution of rare variants to different asthma- or allergy-associated quantitative traits in children with diverse ancestries and explore their role in asthma phenotypes.<h4>Methods</h4>We examined whole-genome sequencing data from children participants in longitudinal studies of asthma (n = 1035; parent-identified as 67% Black and 25% Hispanic) to identify rare variants (minor allele frequency < 0.01). The Journal of allergy and clinical immunologyGene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.PMC10939893UL1 TR000075M01 RR000052UL1 TR000150M01 RR000071R01 CA287257UL1 TR001422P30 ES005605UL1 TR000451UL1 TR000077UL1 TR001105HHSN272201000052IUM1 AI160040KL2 TR002542HHSN272200900052CP30 DK054759TL1 TR002388M01 RR000533UM1 AI114271UG3 OD035521U19 AI162310UL1 RR025780UM2 AI117870T32 HL007605UL1 TR000040DP2 CA247831UL1 TR001873UL1 TR001079UL1 TR001430UG3 OD023282T32 GM007197UH3 OD023282R01 HL104608UH2 AI144434UL1 RR025771U01 AI178772Clay SCohen RTBacharier LBKim HO'Connor GTBusse WWGern JEWood RAJackson DJSmith NPDapas MKhurana Hershey GKGill MAVillani ACCho JLOber CLiu AHGergen PJVisness CMKattan MKercsmar CMRastogi DMedoff BDRivera-Spoljaric KGruchalla RSRobison RGAlladina JfalseGene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.<h4>Background</h4>Most genetic studies of asthma and allergy have focused on common variation in individuals primarily of European ancestry. Studying the role of rare variation in quantitative phenotypes and in asthma phenotypes in populations of diverse ancestries can provide additional, important insights into the development of these traits.<h4>Objective</h4>We sought to examine the contribution of rare variants to different asthma- or allergy-associated quantitative traits in children with diverse ancestries and explore their role in asthma phenotypes.<h4>Methods</h4>We examined whole-genome sequencing data from children participants in longitudinal studies of asthma (n = 1035; parent-identified as 67% Black and 25% Hispanic) to identify rare variants (minor allele frequency < 0.01). 2024-01-01T00:00:00Z2024 Mar2026-06-03T01:39:15.503Z2024-11-19T23:32:34.225ZS-EPMC109398933794456710.1016/j.jaci.2023.10.023