{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan G"],"funding":["NHLBI NIH HHS"],"pagination":["482-501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10940206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134(5)"],"pubmed_abstract":["<h4>Background</h4>Mitochondrial dysfunction is a primary driver of cardiac contractile failure; yet, the cross talk between mitochondrial energetics and signaling regulation remains obscure. Ponatinib, a tyrosine kinase inhibitor used to treat chronic myeloid leukemia, is among the most cardiotoxic tyrosine kinase inhibitors and causes mitochondrial dysfunction. Whether ponatinib-induced mitochondrial dysfunction triggers the integrated stress response (ISR) to induce ponatinib-induced cardiotoxicity remains to be determined.<h4>Methods</h4>Using human induced pluripotent stem cells-derived cardiomyocytes and a recently developed mouse model of ponatinib-induced cardiotoxicity, we performed proteomic analysis, molecular and biochemical assays to investigate the relationship between ponati"],"journal":["Circulation research"],"pubmed_title":["Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity."],"pmcid":["PMC10940206"],"funding_grant_id":["R00 HL130416","R01 HL164729","R01 HL149891","R01 HL148756","K99 HL130416","R01 HL162584","T32 HL007829","R01 HL133080"],"pubmed_authors":["Ong SG","Pinho S","Kwon Y","Jousma J","Du X","Han Z","Ong SB","Lee WH","Prosser BL","Yan G","Nukala SB"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity.","description":"<h4>Background</h4>Mitochondrial dysfunction is a primary driver of cardiac contractile failure; yet, the cross talk between mitochondrial energetics and signaling regulation remains obscure. Ponatinib, a tyrosine kinase inhibitor used to treat chronic myeloid leukemia, is among the most cardiotoxic tyrosine kinase inhibitors and causes mitochondrial dysfunction. Whether ponatinib-induced mitochondrial dysfunction triggers the integrated stress response (ISR) to induce ponatinib-induced cardiotoxicity remains to be determined.<h4>Methods</h4>Using human induced pluripotent stem cells-derived cardiomyocytes and a recently developed mouse model of ponatinib-induced cardiotoxicity, we performed proteomic analysis, molecular and biochemical assays to investigate the relationship between ponati","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-03T23:32:28.35Z","creation":"2025-04-03T23:32:28.35Z"},"accession":"S-EPMC10940206","cross_references":{"pubmed":["38323474"],"doi":["10.1161/CIRCRESAHA.123.323683","10.1161/circresaha.123.323683"]}}