{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bravo CA"],"funding":["NCATS NIH HHS","NIA NIH HHS","NIDA NIH HHS","NIAID NIH HHS","NIMH NIH HHS","NHLBI NIH HHS"],"pagination":["651-659"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10940210"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(3)"],"pubmed_abstract":["<h4>Background</h4>HIV and hepatitis C virus (HCV) are associated with increased risk of carotid artery atherosclerotic plaque and stroke. We examined associations of HIV- and HCV-related factors with echomorphologic features of carotid artery plaque.<h4>Methods</h4>This cross-sectional study included participants from the MACS (Multicenter AIDS Cohort Study)/WIHS (Women's Interagency HIV Study) Combined Cohort Study who underwent high-resolution B-mode carotid artery ultrasound. Plaques were characterized from 6 areas of the right carotid artery. Poisson regression controlling for demographic and cardiometabolic risk factors determined adjusted prevalence ratios (aPRs) and 95% CIs for associations of HIV- and HCV-related factors with echomorphologic features.<h4>Results</h4>Of 2655 participants (65% women, median age 44 [interquartile range, 37-50] years), 1845 (70%) were living with HIV, 600 (23%) were living with HCV, and 425 (16%) had carotid plaque. There were 191 plaques identified in 129 (11%) women with HIV, 51 plaques in 32 (7%) women without HIV, 248 plaques in 171 (28%) men with HIV, and 139 plaques in 93 (29%) men without HIV. Adjusted analyses showed that people with HIV and current CD4<sup>+</sup> count <200 cells/µL had a significantly higher prevalence of predominantly echolucent plaque (aPR, 1.86 [95% CI, 1.08-3.21]) than those without HIV. HCV infection alone (aPR, 1.86 [95% CI, 1.08-3.19]) and HIV-HCV coinfection (aPR, 1.75 [95% CI, 1.10-2.78]) were each associated with higher prevalence of predominantly echogenic plaque. HIV-HCV coinfection was also associated with higher prevalence of smooth surface plaque (aPR, 2.75 [95% CI, 1.03-7.32]) compared with people without HIV and HCV.<h4>Conclusions</h4>HIV with poor immunologic control, as well as HCV infection, either alone or in the presence of HIV, were associated with different echomorphologic phenotypes of carotid artery plaque."],"journal":["Stroke"],"pubmed_title":["Association of HIV and HCV Infection With Carotid Artery Plaque Echomorphology in the MACS/WIHS Combined Cohort Study."],"pmcid":["PMC10940210"],"funding_grant_id":["P30 AI050410","R01 HL148094","R01 HL125053","K01 HL137557","UL1 TR001881","U01 HL146205","U01 HL146204","U01 HL146208","U01 HL146242","L30 DA017071","U01 HL146240","KL2 TR001432","UL1 TR001409","U01 HL146202","U01 HL146201","U01 HL146245","TL1 TR001431","R01 HL144937","R01 HL140976","R01 HL126543","P30 MH116867","P30 AI027767","P30 AI073961","UL1 TR003098","R01 HL095140","P30 AI051519","R01 HL095129","UL1 TR000004","U01 AI035039","P30 AI050409","R21 AG060860","P30 MH133399","U01 HL146333","U01 HL146194","U01 HL146193","R01 HL083760"],"pubmed_authors":["Yan M","Rodriguez CJ","Witt MD","Pyslar N","Kingsley LA","Tien PC","Palella FJ","Li Y","Moon JY","Anastos K","Hodis HN","Hanna DB","Post WS","Gange SJ","Davy K","Lazar JM","Mack WJ","Kassaye SG","Bravo CA","Kaplan RC"],"additional_accession":[]},"is_claimable":false,"name":"Association of HIV and HCV Infection With Carotid Artery Plaque Echomorphology in the MACS/WIHS Combined Cohort Study.","description":"<h4>Background</h4>HIV and hepatitis C virus (HCV) are associated with increased risk of carotid artery atherosclerotic plaque and stroke. We examined associations of HIV- and HCV-related factors with echomorphologic features of carotid artery plaque.<h4>Methods</h4>This cross-sectional study included participants from the MACS (Multicenter AIDS Cohort Study)/WIHS (Women's Interagency HIV Study) Combined Cohort Study who underwent high-resolution B-mode carotid artery ultrasound. Plaques were characterized from 6 areas of the right carotid artery. Poisson regression controlling for demographic and cardiometabolic risk factors determined adjusted prevalence ratios (aPRs) and 95% CIs for associations of HIV- and HCV-related factors with echomorphologic features.<h4>Results</h4>Of 2655 participants (65% women, median age 44 [interquartile range, 37-50] years), 1845 (70%) were living with HIV, 600 (23%) were living with HCV, and 425 (16%) had carotid plaque. There were 191 plaques identified in 129 (11%) women with HIV, 51 plaques in 32 (7%) women without HIV, 248 plaques in 171 (28%) men with HIV, and 139 plaques in 93 (29%) men without HIV. Adjusted analyses showed that people with HIV and current CD4<sup>+</sup> count <200 cells/µL had a significantly higher prevalence of predominantly echolucent plaque (aPR, 1.86 [95% CI, 1.08-3.21]) than those without HIV. HCV infection alone (aPR, 1.86 [95% CI, 1.08-3.19]) and HIV-HCV coinfection (aPR, 1.75 [95% CI, 1.10-2.78]) were each associated with higher prevalence of predominantly echogenic plaque. HIV-HCV coinfection was also associated with higher prevalence of smooth surface plaque (aPR, 2.75 [95% CI, 1.03-7.32]) compared with people without HIV and HCV.<h4>Conclusions</h4>HIV with poor immunologic control, as well as HCV infection, either alone or in the presence of HIV, were associated with different echomorphologic phenotypes of carotid artery plaque.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-03T23:44:12.51Z","creation":"2025-04-03T23:44:12.51Z"},"accession":"S-EPMC10940210","cross_references":{"pubmed":["38333992"],"doi":["10.1161/strokeaha.123.043922","10.1161/STROKEAHA.123.043922"]}}