{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Delpero M"],"funding":["Deutsche Forschungsgemeinschaft","Deutsche Diabetes Gesellschaft","Humboldt-Universität zu Berlin"],"pagination":["6159"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10940635"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The Berlin Fat Mouse Inbred line (BFMI) is a model for obesity and metabolic syndrome. The sublines BFMI861-S1 and BFMI861-S2 differ in weight despite high genetic similarity and a shared obesity-related locus. This study focused on identifying additional body weight quantitative trait loci (QTLs) by analyzing weekly weight measurements in a male population of the advanced intercross line BFMI861-S1 x BFMI861-S2. QTL analysis, utilizing 200 selectively genotyped mice (GigaMUGA) and 197 males genotyped for top SNPs, revealed a genome-wide significant QTL on Chr 15 (68.46 to 81.40 Mb) for body weight between weeks 9 to 20. Notably, this QTL disappeared (weeks 21 to 23) and reappeared (weeks 24 and 25) coinciding with a diet change. Additionally, a significant body weight QTL on Chr 16 (3.89 "],"journal":["Scientific reports"],"pubmed_title":["Identification of additional body weight QTLs in the Berlin Fat Mouse BFMI861 lines using time series data."],"pmcid":["PMC10940635"],"funding_grant_id":["HE8165/1-1"],"pubmed_authors":["Brockmann GA","Delpero M","Arends D","Korkuc P","Hesse D"],"additional_accession":[]},"is_claimable":false,"name":"Identification of additional body weight QTLs in the Berlin Fat Mouse BFMI861 lines using time series data.","description":"The Berlin Fat Mouse Inbred line (BFMI) is a model for obesity and metabolic syndrome. The sublines BFMI861-S1 and BFMI861-S2 differ in weight despite high genetic similarity and a shared obesity-related locus. This study focused on identifying additional body weight quantitative trait loci (QTLs) by analyzing weekly weight measurements in a male population of the advanced intercross line BFMI861-S1 x BFMI861-S2. QTL analysis, utilizing 200 selectively genotyped mice (GigaMUGA) and 197 males genotyped for top SNPs, revealed a genome-wide significant QTL on Chr 15 (68.46 to 81.40 Mb) for body weight between weeks 9 to 20. Notably, this QTL disappeared (weeks 21 to 23) and reappeared (weeks 24 and 25) coinciding with a diet change. Additionally, a significant body weight QTL on Chr 16 (3.89 ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-01T03:22:09.741Z","creation":"2024-11-14T20:32:09.111Z"},"accession":"S-EPMC10940635","cross_references":{"pubmed":["38486030"],"doi":["10.1038/s41598-024-56097-z"]}}