biostudies-literatureDelpero MDeutsche ForschungsgemeinschaftDeutsche Diabetes GesellschaftHumboldt-Universität zu Berlin6159https://www.ebi.ac.uk/biostudies/studies/S-EPMC10940635biostudies-literatureUnknown14(1)The Berlin Fat Mouse Inbred line (BFMI) is a model for obesity and metabolic syndrome. The sublines BFMI861-S1 and BFMI861-S2 differ in weight despite high genetic similarity and a shared obesity-related locus. This study focused on identifying additional body weight quantitative trait loci (QTLs) by analyzing weekly weight measurements in a male population of the advanced intercross line BFMI861-S1 x BFMI861-S2. QTL analysis, utilizing 200 selectively genotyped mice (GigaMUGA) and 197 males genotyped for top SNPs, revealed a genome-wide significant QTL on Chr 15 (68.46 to 81.40 Mb) for body weight between weeks 9 to 20. Notably, this QTL disappeared (weeks 21 to 23) and reappeared (weeks 24 and 25) coinciding with a diet change. Additionally, a significant body weight QTL on Chr 16 (3.89 Scientific reportsIdentification of additional body weight QTLs in the Berlin Fat Mouse BFMI861 lines using time series data.PMC10940635HE8165/1-1Brockmann GADelpero MArends DKorkuc PHesse DfalseIdentification of additional body weight QTLs in the Berlin Fat Mouse BFMI861 lines using time series data.The Berlin Fat Mouse Inbred line (BFMI) is a model for obesity and metabolic syndrome. The sublines BFMI861-S1 and BFMI861-S2 differ in weight despite high genetic similarity and a shared obesity-related locus. This study focused on identifying additional body weight quantitative trait loci (QTLs) by analyzing weekly weight measurements in a male population of the advanced intercross line BFMI861-S1 x BFMI861-S2. QTL analysis, utilizing 200 selectively genotyped mice (GigaMUGA) and 197 males genotyped for top SNPs, revealed a genome-wide significant QTL on Chr 15 (68.46 to 81.40 Mb) for body weight between weeks 9 to 20. Notably, this QTL disappeared (weeks 21 to 23) and reappeared (weeks 24 and 25) coinciding with a diet change. Additionally, a significant body weight QTL on Chr 16 (3.89 2024-01-01T00:00:00Z2024 Mar2026-07-01T03:22:09.741Z2024-11-14T20:32:09.111ZS-EPMC109406353848603010.1038/s41598-024-56097-z