{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang TY"],"funding":["NSF","Simons Foundation","Mia Neri Foundation","NCI NIH HHS","NIH","Cancer Prevention and Research Institute of Texas","NIH HHS"],"pagination":["RP89262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10942579"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Angiogenesis is a morphogenic process resulting in the formation of new blood vessels from pre-existing ones, usually in hypoxic micro-environments. The initial steps of angiogenesis depend on robust differentiation of oligopotent endothelial cells into the Tip and Stalk phenotypic cell fates, controlled by NOTCH-dependent cell-cell communication. The dynamics of spatial patterning of this cell fate specification are only partially understood. Here, by combining a controlled experimental angiogenesis model with mathematical and computational analyses, we find that the regular spatial Tip-Stalk cell patterning can undergo an order-disorder transition at a relatively high input level of a pro-angiogenic factor VEGF. The resulting differentiation is robust but temporally unstable for most cel"],"journal":["eLife"],"pubmed_title":["Spatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification."],"pmcid":["PMC10942579"],"funding_grant_id":["NSF-PHY-2210291","U54 CA209992","DMS1763272","594598","PHY-2019745","NCI U54 CA209992","CPRIT Scholar in Cancer Research"],"pubmed_authors":["Kang TY","Levchenko A","Bocci F","Nie Q","Onuchic JN"],"additional_accession":[]},"is_claimable":false,"name":"Spatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification.","description":"Angiogenesis is a morphogenic process resulting in the formation of new blood vessels from pre-existing ones, usually in hypoxic micro-environments. The initial steps of angiogenesis depend on robust differentiation of oligopotent endothelial cells into the Tip and Stalk phenotypic cell fates, controlled by NOTCH-dependent cell-cell communication. The dynamics of spatial patterning of this cell fate specification are only partially understood. Here, by combining a controlled experimental angiogenesis model with mathematical and computational analyses, we find that the regular spatial Tip-Stalk cell patterning can undergo an order-disorder transition at a relatively high input level of a pro-angiogenic factor VEGF. The resulting differentiation is robust but temporally unstable for most cel","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-04T20:18:37.682Z","creation":"2025-04-04T20:18:37.682Z"},"accession":"S-EPMC10942579","cross_references":{"pubmed":["38376371"],"doi":["10.7554/eLife.89262"]}}