{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Koga K"],"funding":["MEXT | Japan Society for the Promotion of Science","Naito Foundation","Nakatomi Foundation","Hyogo College of Medicine","MEXT | Japan Society for the Promotion of Science (JSPS)","Takeda Science Foundation","Japan Agency for Medical Research and Development","Uehara Memorial Foundation","Japan Agency for Medical Research and Development (AMED)"],"pagination":["330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10943010"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(1)"],"pubmed_abstract":["The anterior cingulate cortex (ACC) responds to noxious and innocuous sensory inputs, and integrates them to coordinate appropriate behavioral reactions. However, the role of the projections of ACC neurons to subcortical areas and their influence on sensory processing are not fully investigated. Here, we identified that ACC neurons projecting to the contralateral claustrum (ACC<sup>→contraCLA</sup>) preferentially respond to contralateral mechanical sensory stimulation. These sensory responses were enhanced during attending behavior. Optogenetic activation of ACC<sup>→contraCLA</sup> neurons silenced pyramidal neurons in the contralateral ACC by recruiting local circuit fast-spiking interneuron activation via an excitatory relay in the CLA. This circuit activation suppressed withdrawal behavior to mechanical stimuli ipsilateral to the ACC<sup>→contraCLA</sup> neurons. Chemogenetic silencing showed that the cross-hemispheric circuit has an important role in the suppression of contralateral nociceptive behavior during sensory-driven attending behavior. Our findings identify a cross-hemispheric cortical-subcortical-cortical arc allowing the brain to give attentional priority to competing innocuous and noxious inputs."],"journal":["Communications biology"],"pubmed_title":["Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict."],"pmcid":["PMC10943010"],"funding_grant_id":["22K15206","23K18441","20K16133","Hyogo Innovative Challenge grant","JP23gm1510013","JPMXP0723833162","JP22H04922 (AdAMS)","Grant for Research Promotion 2023","Grant for Research Promotion 2021","20H04043"],"pubmed_authors":["Furue H","Tsuda M","Pickering AE","Koga K","Kobayashi K"],"additional_accession":[]},"is_claimable":false,"name":"Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict.","description":"The anterior cingulate cortex (ACC) responds to noxious and innocuous sensory inputs, and integrates them to coordinate appropriate behavioral reactions. However, the role of the projections of ACC neurons to subcortical areas and their influence on sensory processing are not fully investigated. Here, we identified that ACC neurons projecting to the contralateral claustrum (ACC<sup>→contraCLA</sup>) preferentially respond to contralateral mechanical sensory stimulation. These sensory responses were enhanced during attending behavior. Optogenetic activation of ACC<sup>→contraCLA</sup> neurons silenced pyramidal neurons in the contralateral ACC by recruiting local circuit fast-spiking interneuron activation via an excitatory relay in the CLA. This circuit activation suppressed withdrawal behavior to mechanical stimuli ipsilateral to the ACC<sup>→contraCLA</sup> neurons. Chemogenetic silencing showed that the cross-hemispheric circuit has an important role in the suppression of contralateral nociceptive behavior during sensory-driven attending behavior. Our findings identify a cross-hemispheric cortical-subcortical-cortical arc allowing the brain to give attentional priority to competing innocuous and noxious inputs.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-01T03:23:32.405Z","creation":"2025-04-06T17:25:50.544Z"},"accession":"S-EPMC10943010","cross_references":{"pubmed":["38491200"],"doi":["10.1038/s42003-024-06008-9"]}}