{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Karim F"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","Bill and Melinda Gates Foundation","Wellcome Trust","Gates Foundation"],"pagination":["2360"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10943233"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["SARS-CoV-2 clearance requires adaptive immunity but the contribution of neutralizing antibodies and T cells in different immune states is unclear. Here we ask which adaptive immune responses associate with clearance of long-term SARS-CoV-2 infection in HIV-mediated immunosuppression after suppressive antiretroviral therapy (ART) initiation. We assembled a cohort of SARS-CoV-2 infected people in South Africa (n = 994) including participants with advanced HIV disease characterized by immunosuppression due to T cell depletion. Fifty-four percent of participants with advanced HIV disease had prolonged SARS-CoV-2 infection (>1 month). In the five vaccinated participants with advanced HIV disease tested, SARS-CoV-2 clearance associates with emergence of neutralizing antibodies but not SARS-CoV-2"],"journal":["Nature communications"],"pubmed_title":["Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation."],"pmcid":["PMC10943233"],"funding_grant_id":["INV-018944","R01 AI138546","R01AI138546-05","226137/Z/22/Z"],"pubmed_authors":["Hanekom W","Reedoy K","de Oliveira T","Riou C","Abdool Karim SS","Manickchund N","Moore PL","Moosa MS","Upton JL","Govender K","Makhado Z","Sigal A","von Gottberg A","Magula N","Ganga Y","Gosnell BI","Lessells RJ","Burgers WA","Keeton RS","Thambu K","Venter E","Karim QA","Mazibuko M","van Graan S","Lustig G","Karim F","Jule Z","Khan K","Ngcobo N","Bernstein M","Hoque M"],"additional_accession":[]},"is_claimable":false,"name":"Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation.","description":"SARS-CoV-2 clearance requires adaptive immunity but the contribution of neutralizing antibodies and T cells in different immune states is unclear. Here we ask which adaptive immune responses associate with clearance of long-term SARS-CoV-2 infection in HIV-mediated immunosuppression after suppressive antiretroviral therapy (ART) initiation. We assembled a cohort of SARS-CoV-2 infected people in South Africa (n = 994) including participants with advanced HIV disease characterized by immunosuppression due to T cell depletion. Fifty-four percent of participants with advanced HIV disease had prolonged SARS-CoV-2 infection (>1 month). In the five vaccinated participants with advanced HIV disease tested, SARS-CoV-2 clearance associates with emergence of neutralizing antibodies but not SARS-CoV-2","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T08:25:34.124Z","creation":"2024-11-07T11:27:24.633Z"},"accession":"S-EPMC10943233","cross_references":{"pubmed":["38491050"],"doi":["10.1038/s41467-024-46673-2"]}}