biostudies-literatureLolicato FDeutsche Forschungsgemeinschaft105757https://www.ebi.ac.uk/biostudies/studies/S-EPMC10944118biostudies-literatureUnknown300(3)Phosphoinositides are amphipathic lipid molecules derived from phosphatidylinositol that represent low abundance components of biological membranes. Rather than serving as mere structural elements of lipid bilayers, they represent molecular switches for a broad range of biological processes, including cell signaling, membrane dynamics and remodeling, and many other functions. Here, we focus on the molecular mechanisms that turn phosphoinositides into molecular switches and how the dysregulation of these processes can lead to disease.The Journal of biological chemistryPhosphoinositide switches in cell physiology - From molecular mechanisms to disease.PMC10944118Ni 423/13-1SFB/TRR186LO 2821/1-1HA2686/24-1Haucke VLolicato FNickel WEbner MfalsePhosphoinositide switches in cell physiology - From molecular mechanisms to disease.Phosphoinositides are amphipathic lipid molecules derived from phosphatidylinositol that represent low abundance components of biological membranes. Rather than serving as mere structural elements of lipid bilayers, they represent molecular switches for a broad range of biological processes, including cell signaling, membrane dynamics and remodeling, and many other functions. Here, we focus on the molecular mechanisms that turn phosphoinositides into molecular switches and how the dysregulation of these processes can lead to disease.2024-01-01T00:00:00Z2024 Feb2024-11-09T06:17:25.136Z2024-11-09T06:17:25.136ZS-EPMC109441183836488910.1016/j.jbc.2024.105757