{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Le Chapelain O"],"funding":["INCA","ANR","La fondation Arc"],"pagination":["84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10944607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(1)"],"pubmed_abstract":["<h4>Background</h4>How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized.<h4>Methods</h4>We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TME, PyMT AT-3 mammary tumors and B16F1 melanoma.<h4>Results</h4>We show that whereas firmly adherent platelets continuously line tumor vessels of both AT-3 and B16F1 tumors, abundant extravascular stromal clusters of platelets from thrombopoietin-independent origin were present only in AT-3 mammary tumors. We further show that platelets influence the angiogenic and inflammatory profiles of AT-3 and B16F1 tumors, though with very different outcomes according to tumor type. Whereas thrombocytopenia increased bleeding in both tumor types, it "],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent."],"pmcid":["PMC10944607"],"funding_grant_id":["RPT16002MMA","ANR-18-RHUS-0001","PJA 20151203107"],"pubmed_authors":["Solo Nomenjanahary M","Boulaftali Y","Jadoui S","Ho-Tin-Noe B","Barbaria S","Delbosc S","Caligiuri G","Benmeziane K","Nieswandt B","Rogozarski J","Gros A","Mangin PH","Mawhin MA","Ollivier V","Le Chapelain O","Mavouna S","Porteu F","Dupont S"],"additional_accession":[]},"is_claimable":false,"name":"The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent.","description":"<h4>Background</h4>How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized.<h4>Methods</h4>We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TME, PyMT AT-3 mammary tumors and B16F1 melanoma.<h4>Results</h4>We show that whereas firmly adherent platelets continuously line tumor vessels of both AT-3 and B16F1 tumors, abundant extravascular stromal clusters of platelets from thrombopoietin-independent origin were present only in AT-3 mammary tumors. We further show that platelets influence the angiogenic and inflammatory profiles of AT-3 and B16F1 tumors, though with very different outcomes according to tumor type. Whereas thrombocytopenia increased bleeding in both tumor types, it ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-20T02:52:37.001Z","creation":"2025-04-20T02:52:37.001Z"},"accession":"S-EPMC10944607","cross_references":{"pubmed":["38493157"],"doi":["10.1186/s13046-024-03001-2"]}}