biostudies-literatureLe Chapelain OINCAANRLa fondation Arc84https://www.ebi.ac.uk/biostudies/studies/S-EPMC10944607biostudies-literatureUnknown43(1)<h4>Background</h4>How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized.<h4>Methods</h4>We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TME, PyMT AT-3 mammary tumors and B16F1 melanoma.<h4>Results</h4>We show that whereas firmly adherent platelets continuously line tumor vessels of both AT-3 and B16F1 tumors, abundant extravascular stromal clusters of platelets from thrombopoietin-independent origin were present only in AT-3 mammary tumors. We further show that platelets influence the angiogenic and inflammatory profiles of AT-3 and B16F1 tumors, though with very different outcomes according to tumor type. Whereas thrombocytopenia increased bleeding in both tumor types, it Journal of experimental & clinical cancer research : CRThe localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent.PMC10944607RPT16002MMAANR-18-RHUS-0001PJA 20151203107Solo Nomenjanahary MBoulaftali YJadoui SHo-Tin-Noe BBarbaria SDelbosc SCaligiuri GBenmeziane KNieswandt BRogozarski JGros AMangin PHMawhin MAOllivier VLe Chapelain OMavouna SPorteu FDupont SfalseThe localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent.<h4>Background</h4>How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized.<h4>Methods</h4>We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TME, PyMT AT-3 mammary tumors and B16F1 melanoma.<h4>Results</h4>We show that whereas firmly adherent platelets continuously line tumor vessels of both AT-3 and B16F1 tumors, abundant extravascular stromal clusters of platelets from thrombopoietin-independent origin were present only in AT-3 mammary tumors. We further show that platelets influence the angiogenic and inflammatory profiles of AT-3 and B16F1 tumors, though with very different outcomes according to tumor type. Whereas thrombocytopenia increased bleeding in both tumor types, it 2024-01-01T00:00:00Z2024 Mar2025-04-20T02:52:37.001Z2025-04-20T02:52:37.001ZS-EPMC109446073849315710.1186/s13046-024-03001-2