biostudies-literatureUnknown16(2)Sang L<h4>Background</h4>The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible but causes less severe disease compared to other variants. However, its association with sepsis incidence and outcomes is unclear. This study aimed to investigate the incidence of Omicron-associated sepsis, as per the Sepsis 3.0 definition, in hospitalized patients, and to explore its relationship with clinical characteristics and prognosis.<h4>Methods</h4>This multicenter retrospective study included adults hospitalized with confirmed SARS-CoV-2 infection across six tertiary hospitals in Guangzhou, China from November 2022 to January 2023. The Sequential Organ Failure Assessment (SOFA) score and its components were calculated at hospital admission to identify sepsJournal of thoracic disease1313-1323https://www.ebi.ac.uk/biostudies/studies/S-EPMC10944721biostudies-literatureMore attention should be paid to Omicron-associated sepsis: a multicenter retrospective study in south China.PMC10944721Ye WWu HZhong NLiu XLi YLi ZHuang YLi SXian LCheng LLiu CYe FWang YWen DDeng XSang LXu YfalseMore attention should be paid to Omicron-associated sepsis: a multicenter retrospective study in south China.<h4>Background</h4>The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible but causes less severe disease compared to other variants. However, its association with sepsis incidence and outcomes is unclear. This study aimed to investigate the incidence of Omicron-associated sepsis, as per the Sepsis 3.0 definition, in hospitalized patients, and to explore its relationship with clinical characteristics and prognosis.<h4>Methods</h4>This multicenter retrospective study included adults hospitalized with confirmed SARS-CoV-2 infection across six tertiary hospitals in Guangzhou, China from November 2022 to January 2023. The Sequential Organ Failure Assessment (SOFA) score and its components were calculated at hospital admission to identify seps2024-01-01T00:00:00Z2024 Feb2026-07-14T19:48:06.441Z2025-04-06T13:55:20.976ZS-EPMC109447213850501410.21037/jtd-23-808