{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["133(19)"],"submitter":["Anbu S"],"pubmed_abstract":["Manganese-based contrast agents (MnCAs) have emerged as suitable alternatives to gadolinium-based contrast agents (GdCAs). However, due to their kinetic lability and laborious synthetic procedures, only a few MnCAs have found clinical MRI application. In this work, we have employed a highly innovative single-pot template synthetic strategy to develop a MnCA, <b>MnL<sup>Me</sup></b>, and studied the most important physicochemical properties in vitro. <b>MnL<sup>Me</sup></b> displays optimized <i>r</i> <sub>1</sub> relaxivities at both medium (20 and 64 MHz) and high magnetic fields (300 and 400 MHz) and an enhanced <i>r</i> <sub>1</sub> <sup>b</sup>=21.1 mM<sup>-1</sup> s<sup>-1</sup> (20 MHz, 298 K, pH 7.4) upon binding to BSA (<i>K</i> <sub>a</sub>=4.2×10<sup>3</sup> M<sup>-1</sup>). In v"],"journal":["Angewandte Chemie (Weinheim an der Bergstrasse, Germany)"],"pagination":["10831-10839"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947048"],"repository":["biostudies-literature"],"pubmed_title":["A Single-Pot Template Reaction Towards a Manganese-Based <i>T</i><sub>1</sub> Contrast Agent."],"pmcid":["PMC10947048"],"pubmed_authors":["Martins AF","Anbu S","Hoffmann SHL","Kenning L","Carniato F","Price TW","Stasiuk GJ","Prior TJ","Botta M"],"additional_accession":[]},"is_claimable":false,"name":"A Single-Pot Template Reaction Towards a Manganese-Based <i>T</i><sub>1</sub> Contrast Agent.","description":"Manganese-based contrast agents (MnCAs) have emerged as suitable alternatives to gadolinium-based contrast agents (GdCAs). However, due to their kinetic lability and laborious synthetic procedures, only a few MnCAs have found clinical MRI application. In this work, we have employed a highly innovative single-pot template synthetic strategy to develop a MnCA, <b>MnL<sup>Me</sup></b>, and studied the most important physicochemical properties in vitro. <b>MnL<sup>Me</sup></b> displays optimized <i>r</i> <sub>1</sub> relaxivities at both medium (20 and 64 MHz) and high magnetic fields (300 and 400 MHz) and an enhanced <i>r</i> <sub>1</sub> <sup>b</sup>=21.1 mM<sup>-1</sup> s<sup>-1</sup> (20 MHz, 298 K, pH 7.4) upon binding to BSA (<i>K</i> <sub>a</sub>=4.2×10<sup>3</sup> M<sup>-1</sup>). In v","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-26T12:14:30.091Z","creation":"2025-04-06T13:53:57.884Z"},"accession":"S-EPMC10947048","cross_references":{"pubmed":["38505690"],"doi":["10.1002/ange.202100885"]}}