{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yii FS"],"funding":["Medical Research Council"],"pagination":["1412-1418"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947352"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(6)"],"pubmed_abstract":["Purpose
To compare axial length (AL) growth curves in East Asian (EA) and non-EA emmetropes.Methods
A meta-regression of 28 studies with emmetrope-specific AL data (measured with optical biometry) was performed. Emmetropia was defined as spherical equivalent refraction (SER) between -0.50 and +1.25 D, determined under cycloplegia if the mean age was ≤20 years. The AL growth curve (mean AL vs. mean age) was first fitted to the full dataset using a weighted nonlinear mixed-effects model, before refitting the model with ethnicity as a two-level grouping variable (EA vs. non-EA). Ethnic differences in growth curve parameters were tested using the Wald test.Results
A total of 3331 EA and 1071 non-EA emmetropes (mean age: 6.5-23.1 years) were included. There was no evidence of an ethnic difference in either final AL (difference: 0.15 mm, 95% CI: -0.04 to 0.35 mm, p = 0.15) or initial AL, as represented by the amount that the final AL needed to be offset to obtain the y-intercept (difference: -2.77 mm, 95% CI: -10.97 to 5.44, p = 0.51). Likewise, AL growth rate (curve steepness) did not differ between ethnic groups (difference: 0.09, 95% CI: -0.13 to 0.31, p = 0.43). Collectively, AL growth rate decreased from 0.24 mm/year at 6 years of age to around 0.05 mm/year at 11 years of age, after which it dipped below the repeatability of optical biometry (±0.04 mm) and practically plateaued around 16 years of age (final AL: 23.60 mm).Conclusions
EA and non-EA emmetropes have comparable AL growth curves."],"journal":["Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)"],"pubmed_title":["Emmetropic eye growth in East Asians and non-East Asians."],"pmcid":["PMC10947352"],"funding_grant_id":["MR/N013166/1"],"pubmed_authors":["Yii FS"],"additional_accession":[]},"is_claimable":false,"name":"Emmetropic eye growth in East Asians and non-East Asians.","description":"Purpose
To compare axial length (AL) growth curves in East Asian (EA) and non-EA emmetropes.Methods
A meta-regression of 28 studies with emmetrope-specific AL data (measured with optical biometry) was performed. Emmetropia was defined as spherical equivalent refraction (SER) between -0.50 and +1.25 D, determined under cycloplegia if the mean age was ≤20 years. The AL growth curve (mean AL vs. mean age) was first fitted to the full dataset using a weighted nonlinear mixed-effects model, before refitting the model with ethnicity as a two-level grouping variable (EA vs. non-EA). Ethnic differences in growth curve parameters were tested using the Wald test.Results
A total of 3331 EA and 1071 non-EA emmetropes (mean age: 6.5-23.1 years) were included. There was no evidence of an ethnic difference in either final AL (difference: 0.15 mm, 95% CI: -0.04 to 0.35 mm, p = 0.15) or initial AL, as represented by the amount that the final AL needed to be offset to obtain the y-intercept (difference: -2.77 mm, 95% CI: -10.97 to 5.44, p = 0.51). Likewise, AL growth rate (curve steepness) did not differ between ethnic groups (difference: 0.09, 95% CI: -0.13 to 0.31, p = 0.43). Collectively, AL growth rate decreased from 0.24 mm/year at 6 years of age to around 0.05 mm/year at 11 years of age, after which it dipped below the repeatability of optical biometry (±0.04 mm) and practically plateaued around 16 years of age (final AL: 23.60 mm).Conclusions
EA and non-EA emmetropes have comparable AL growth curves.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-14T05:33:37.852Z","creation":"2025-02-19T03:08:23.292Z"},"accession":"S-EPMC10947352","cross_references":{"pubmed":["37368239"],"doi":["10.1111/opo.13195"]}}