{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rooney CHE"],"funding":["British Heart Foundation","Israel Science Foundation","European Commission"],"pagination":["e202300144"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(18)"],"pubmed_abstract":["Deuterated <sup>13</sup> C sites in sugars (D-glucose and 2-deoxy-D-glucose) showed 6.3-to-17.5-fold higher solid-state dynamic nuclear polarization (DNP) levels than their respective protonated sites at 3.35T. This effect was found to be unrelated to the protonation of the bath. Deuterated <sup>15</sup> N in sites bound to exchangeable protons ([<sup>15</sup> N<sub>2</sub> ]urea) showed a 1.3-fold higher polarization than their respective protonated sites at the same magnetic field. This relatively smaller effect was attributed to incomplete deuteration of the <sup>15</sup> N sites due to the solvent mixture. For a <sup>15</sup> N site that is not bound to protons or deuterons ([<sup>15</sup> N]nitrate), deuteration of the bath did not affect the polarization level. These findings suggest a phenomenon related to DNP of X-nuclei directly bound to deuteron(s) as opposed to proton(s). It appears that direct binding to deuterons increases the solid-state DNP polarization level of X-nuclei which are otherwise bound to protons."],"journal":["Chemphyschem : a European journal of chemical physics and physical chemistry"],"pubmed_title":["Directly Bound Deuterons Increase X-Nuclei Hyperpolarization using Dynamic Nuclear Polarization."],"pmcid":["PMC10947409"],"funding_grant_id":["FS/19/18/34252","1379/18","858149"],"pubmed_authors":["Tyler DJ","Rooney CHE","Katz-Brull R","Grist JT","Shaul D","Gamliel A"],"additional_accession":[]},"is_claimable":false,"name":"Directly Bound Deuterons Increase X-Nuclei Hyperpolarization using Dynamic Nuclear Polarization.","description":"Deuterated <sup>13</sup> C sites in sugars (D-glucose and 2-deoxy-D-glucose) showed 6.3-to-17.5-fold higher solid-state dynamic nuclear polarization (DNP) levels than their respective protonated sites at 3.35T. This effect was found to be unrelated to the protonation of the bath. Deuterated <sup>15</sup> N in sites bound to exchangeable protons ([<sup>15</sup> N<sub>2</sub> ]urea) showed a 1.3-fold higher polarization than their respective protonated sites at the same magnetic field. This relatively smaller effect was attributed to incomplete deuteration of the <sup>15</sup> N sites due to the solvent mixture. For a <sup>15</sup> N site that is not bound to protons or deuterons ([<sup>15</sup> N]nitrate), deuteration of the bath did not affect the polarization level. These findings suggest a phenomenon related to DNP of X-nuclei directly bound to deuteron(s) as opposed to proton(s). It appears that direct binding to deuterons increases the solid-state DNP polarization level of X-nuclei which are otherwise bound to protons.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-20T02:49:43.468Z","creation":"2025-02-19T03:09:12.823Z"},"accession":"S-EPMC10947409","cross_references":{"pubmed":["37431622"],"doi":["10.1002/cphc.202300144"]}}