{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(7)"],"submitter":["Boonpor J"],"funding":["Northwest Regional Development Agency","Medical Research Council","Wellcome Trust","Scottish Government"],"pubmed_abstract":["<h4>Aims</h4>To investigate the combined association of adiposity and walking pace with incident type 2 diabetes.<h4>Methods</h4>We undertook a prospective cohort study in 194 304 White-European participants (mean age 56.5 years, 55.9% women). Participants' walking pace was self-reported as brisk, average or slow. Adiposity measures included body mass index (BMI), waist circumference (WC) and body fat percentage (BF%). Associations were investigated using Cox proportional hazard models, with a 2-year landmark analysis. A four-way decomposition analysis was used for mediation and additive interaction.<h4>Results</h4>The median (interquartile range) follow-up was 5.4 (4.8-6.3) years. During the follow-up period, 4564 participants developed type 2 diabetes. Compared to brisk-walking participants with normal BMI, those with obesity who walked briskly were at an approximately 10- to 12-fold higher risk of type 2 diabetes (hazard ratio [HR] 9.64, 95% confidence interval [CI] 7.24-12.84, in women; HR 11.91, 95% CI 8.80-16.12, in men), whereas those with obesity and walked slowly had an approximately 12- to 15-fold higher risk (HR 12.68, 95% CI 9.62-16.71, in women; HR 15.41, 95% CI 11.27-21.06, in men). There was evidence of an additive interaction between WC and BF% and walking pace among women, explaining 17.8% and 47.9% excess risk respectively. Obesity mediated the association in women and men, accounting for 60.1% and 44.9%, respectively.<h4>Conclusions</h4>Slow walking pace is a risk factor for type 2 diabetes independent of adiposity. Promoting brisk walking as well as weight management might be an effective type 2 diabetes prevention strategy given their synergistic effects."],"journal":["Diabetes, obesity & metabolism"],"pagination":["1900-1910"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947435"],"repository":["biostudies-literature"],"pubmed_title":["Association between walking pace and incident type 2 diabetes by adiposity level: A prospective cohort study from the UK Biobank."],"pmcid":["PMC10947435"],"pubmed_authors":["Lynskey N","Talebi A","Celis-Morales CA","Sattar N","Gray SR","Raisi A","Ho FK","Gore J","Welsh P","Pell JP","Boonpor J","Parra-Soto S","Gill JMR"],"additional_accession":[]},"is_claimable":false,"name":"Association between walking pace and incident type 2 diabetes by adiposity level: A prospective cohort study from the UK Biobank.","description":"<h4>Aims</h4>To investigate the combined association of adiposity and walking pace with incident type 2 diabetes.<h4>Methods</h4>We undertook a prospective cohort study in 194 304 White-European participants (mean age 56.5 years, 55.9% women). Participants' walking pace was self-reported as brisk, average or slow. Adiposity measures included body mass index (BMI), waist circumference (WC) and body fat percentage (BF%). Associations were investigated using Cox proportional hazard models, with a 2-year landmark analysis. A four-way decomposition analysis was used for mediation and additive interaction.<h4>Results</h4>The median (interquartile range) follow-up was 5.4 (4.8-6.3) years. During the follow-up period, 4564 participants developed type 2 diabetes. Compared to brisk-walking participants with normal BMI, those with obesity who walked briskly were at an approximately 10- to 12-fold higher risk of type 2 diabetes (hazard ratio [HR] 9.64, 95% confidence interval [CI] 7.24-12.84, in women; HR 11.91, 95% CI 8.80-16.12, in men), whereas those with obesity and walked slowly had an approximately 12- to 15-fold higher risk (HR 12.68, 95% CI 9.62-16.71, in women; HR 15.41, 95% CI 11.27-21.06, in men). There was evidence of an additive interaction between WC and BF% and walking pace among women, explaining 17.8% and 47.9% excess risk respectively. Obesity mediated the association in women and men, accounting for 60.1% and 44.9%, respectively.<h4>Conclusions</h4>Slow walking pace is a risk factor for type 2 diabetes independent of adiposity. Promoting brisk walking as well as weight management might be an effective type 2 diabetes prevention strategy given their synergistic effects.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2026-06-23T03:18:42.062Z","creation":"2025-05-29T22:16:51.184Z"},"accession":"S-EPMC10947435","cross_references":{"pubmed":["36951683"],"doi":["10.1111/dom.15053"]}}