{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu J"],"funding":["NIMH NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["419-430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947504"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(2)"],"pubmed_abstract":["<h4>Background</h4>Post-traumatic stress disorder (PTSD) is associated with cognitive impairments. It is unclear whether problems persist after PTSD symptoms remit.<h4>Methods</h4>Data came from 12 270 trauma-exposed women in the Nurses' Health Study II. Trauma and PTSD symptoms were assessed using validated scales to determine PTSD status as of 2008 (trauma/no PTSD, remitted PTSD, unresolved PTSD) and symptom severity (lifetime and past-month). Starting in 2014, cognitive function was assessed using the Cogstate Brief Battery every 6 or 12 months for up to 24 months. PTSD associations with baseline cognition and longitudinal cognitive changes were estimated by covariate-adjusted linear regression and linear mixed-effects models, respectively.<h4>Results</h4>Compared to women with trauma/no PTSD, women with remitted PTSD symptoms had a similar cognitive function at baseline, while women with unresolved PTSD symptoms had worse psychomotor speed/attention and learning/working memory. In women with unresolved PTSD symptoms, past-month PTSD symptom severity was inversely associated with baseline cognition. Over follow-up, both women with remitted and unresolved PTSD symptoms in 2008, especially those with high levels of symptoms, had a faster decline in learning/working memory than women with trauma/no PTSD. In women with remitted PTSD symptoms, higher lifetime PTSD symptom severity was associated with a faster decline in learning/working memory. Results were robust to the adjustment for sociodemographic, biobehavioral, and health factors and were partially attenuated when adjusted for depression.<h4>Conclusion</h4>Unresolved but not remitted PTSD was associated with worse cognitive function assessed six years later. Accelerated cognitive decline was observed among women with either unresolved or remitted PTSD symptoms."],"journal":["Psychological medicine"],"pubmed_title":["Post-traumatic stress disorder symptom remission and cognition in a large cohort of civilian women."],"pmcid":["PMC10947504"],"funding_grant_id":["R01 MH101269","T32 HL098048","UM1 CA176726","R21 MH102570","U01 CA176726","R01 MH078928"],"pubmed_authors":["Roberts AL","Jha SC","Liu J","Kubzansky LD","Grodstein F","Haneuse S","Chibnik LB","Kang JH","Liang L","Koenen KC","Lawn RB","Rimm EB","Sampson L","Sumner JA"],"additional_accession":[]},"is_claimable":false,"name":"Post-traumatic stress disorder symptom remission and cognition in a large cohort of civilian women.","description":"<h4>Background</h4>Post-traumatic stress disorder (PTSD) is associated with cognitive impairments. It is unclear whether problems persist after PTSD symptoms remit.<h4>Methods</h4>Data came from 12 270 trauma-exposed women in the Nurses' Health Study II. Trauma and PTSD symptoms were assessed using validated scales to determine PTSD status as of 2008 (trauma/no PTSD, remitted PTSD, unresolved PTSD) and symptom severity (lifetime and past-month). Starting in 2014, cognitive function was assessed using the Cogstate Brief Battery every 6 or 12 months for up to 24 months. PTSD associations with baseline cognition and longitudinal cognitive changes were estimated by covariate-adjusted linear regression and linear mixed-effects models, respectively.<h4>Results</h4>Compared to women with trauma/no PTSD, women with remitted PTSD symptoms had a similar cognitive function at baseline, while women with unresolved PTSD symptoms had worse psychomotor speed/attention and learning/working memory. In women with unresolved PTSD symptoms, past-month PTSD symptom severity was inversely associated with baseline cognition. Over follow-up, both women with remitted and unresolved PTSD symptoms in 2008, especially those with high levels of symptoms, had a faster decline in learning/working memory than women with trauma/no PTSD. In women with remitted PTSD symptoms, higher lifetime PTSD symptom severity was associated with a faster decline in learning/working memory. Results were robust to the adjustment for sociodemographic, biobehavioral, and health factors and were partially attenuated when adjusted for depression.<h4>Conclusion</h4>Unresolved but not remitted PTSD was associated with worse cognitive function assessed six years later. Accelerated cognitive decline was observed among women with either unresolved or remitted PTSD symptoms.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-05-03T21:53:53.884Z","creation":"2026-04-07T19:38:49.98Z"},"accession":"S-EPMC10947504","cross_references":{"pubmed":["37577959"],"doi":["10.1017/s0033291723001915","10.1017/S0033291723001915"]}}