{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Paneitz DC"],"funding":["NICHD NIH HHS","National Institutes of Health"],"pagination":["745-751"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947752"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(6)"],"pubmed_abstract":["<h4>Background</h4>Failure to thrive (FTT), defined as weight or height less than the lowest 2.5 percentile for age, is prevalent in up to 66% of children with congenital heart disease (CHD). Risk stratification methods to identify those who would benefit from early intervention are currently lacking. We aimed to identify a novel growth biomarker to aid clinical decision-making in children with CHD.<h4>Methods</h4>This is a cross-sectional study of patients 2 months to 10 years of age with any CHD undergoing cardiac surgery. Preoperative weight-for-age Z scores (WAZ) and height-for-age Z scores (HAZ) were calculated and assessed for association with preoperative plasma biomarkers: growth differentiation factor 15 (GDF-15), fibroblast growth factor 21, leptin, prealbumin, and C-reactive protein (CRP).<h4>Results</h4>Of the 238 patients included, approximately 70% of patients had WAZ/HAZ < 0 and 34% had FTT. There was a moderate correlation between GDF-15 and WAZ/HAZ. When stratified by age, the correlation of GDF-15 to WAZ and HAZ was strongest in children under 2 years of age and persisted in the setting of inflammation (CRP > 0.5 mg/dL). Diagnoses commonly associated with congestive heart failure had high proportions of FTT and median GDF-15 levels. Prealbumin was not correlated with WAZ or HAZ.<h4>Conclusions</h4>GDF-15 represents an important growth biomarker in children with CHD, especially those under 2 years of age who have diagnoses commonly associated with CHF. Our data do not support prealbumin as a long-term growth biomarker."],"journal":["World journal for pediatric & congenital heart surgery"],"pubmed_title":["Growth Differentiation Factor 15: A Novel Growth Biomarker for Children With Congenital Heart Disease."],"pmcid":["PMC10947752"],"funding_grant_id":["R01 HD084461","TR002243","HD084461"],"pubmed_authors":["Zhou A","Golla S","Yanek L","Paneitz DC","Gottlieb Sen D","Everett AD","Kannankeril PJ","Avula S","Mettler BA"],"additional_accession":[]},"is_claimable":false,"name":"Growth Differentiation Factor 15: A Novel Growth Biomarker for Children With Congenital Heart Disease.","description":"<h4>Background</h4>Failure to thrive (FTT), defined as weight or height less than the lowest 2.5 percentile for age, is prevalent in up to 66% of children with congenital heart disease (CHD). Risk stratification methods to identify those who would benefit from early intervention are currently lacking. We aimed to identify a novel growth biomarker to aid clinical decision-making in children with CHD.<h4>Methods</h4>This is a cross-sectional study of patients 2 months to 10 years of age with any CHD undergoing cardiac surgery. Preoperative weight-for-age Z scores (WAZ) and height-for-age Z scores (HAZ) were calculated and assessed for association with preoperative plasma biomarkers: growth differentiation factor 15 (GDF-15), fibroblast growth factor 21, leptin, prealbumin, and C-reactive protein (CRP).<h4>Results</h4>Of the 238 patients included, approximately 70% of patients had WAZ/HAZ < 0 and 34% had FTT. There was a moderate correlation between GDF-15 and WAZ/HAZ. When stratified by age, the correlation of GDF-15 to WAZ and HAZ was strongest in children under 2 years of age and persisted in the setting of inflammation (CRP > 0.5 mg/dL). Diagnoses commonly associated with congestive heart failure had high proportions of FTT and median GDF-15 levels. Prealbumin was not correlated with WAZ or HAZ.<h4>Conclusions</h4>GDF-15 represents an important growth biomarker in children with CHD, especially those under 2 years of age who have diagnoses commonly associated with CHF. Our data do not support prealbumin as a long-term growth biomarker.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T12:06:46.811Z","creation":"2025-02-19T03:09:09.848Z"},"accession":"S-EPMC10947752","cross_references":{"pubmed":["36300261"],"doi":["10.1177/21501351221118080"]}}