biostudies-literatureSacca VNCCIH NIH HHSNIDA NIH HHSNIA NIH HHSNINDS NIH HHS608-619https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947961biostudies-literatureUnknown28(4)<h4>Background</h4>Low back pain (LBP) is a major public health issue that influences physical and emotional factors integral to the limbic system. This study aims to investigate the association between LBP and brain morphometry alterations as the duration of LBP increases (acute vs. chronic).<h4>Methods</h4>We used the UK Biobank data to investigate the morphological features of the limbic system in acute LBP (N = 115), chronic LBP (N = 243) and controls (N = 358), and tried to replicate our findings with an independent dataset composed of 45 acute LBP participants evaluated at different timepoints throughout 1 year from the OpenPain database.<h4>Results</h4>We found that in comparison with chronic LBP and pain-free controls, acute LBP was associated with increased volumes of the nucleus European journal of pain (London, England)Morphological changes of the limbic system associated with acute and chronic low-back pain: A UK biobank imaging study.PMC10947961R01 NS129059R34 DA046635R01 AG063975R33 AT009341R01 AT008563R33 AT009310Hodges SGe TAmores JSacca VTodorova NChai-Zhang TCGuler SKong JMcDonald CMfalseMorphological changes of the limbic system associated with acute and chronic low-back pain: A UK biobank imaging study.<h4>Background</h4>Low back pain (LBP) is a major public health issue that influences physical and emotional factors integral to the limbic system. This study aims to investigate the association between LBP and brain morphometry alterations as the duration of LBP increases (acute vs. chronic).<h4>Methods</h4>We used the UK Biobank data to investigate the morphological features of the limbic system in acute LBP (N = 115), chronic LBP (N = 243) and controls (N = 358), and tried to replicate our findings with an independent dataset composed of 45 acute LBP participants evaluated at different timepoints throughout 1 year from the OpenPain database.<h4>Results</h4>We found that in comparison with chronic LBP and pain-free controls, acute LBP was associated with increased volumes of the nucleus 2024-01-01T00:00:00Z2024 Apr2025-07-02T03:04:31.163Z2025-07-02T03:04:31.163ZS-EPMC109479613800939310.1002/ejp.2206