{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Beck ED"],"funding":["NIA NIH HHS","National Institutes of Health","NIH HHS","National Institute on Aging"],"pagination":["1497-1514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947984"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["<h4>Introduction</h4>The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear.<h4>Methods</h4>Using data from eight independent studies (N<sub>total</sub> = 44,531; N<sub>dementia</sub> = 1703; baseline M<sub>age</sub> = 49 to 81 years, 26 to 61% female; M<sub>follow-up</sub> range = 3.53 to 21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia.<h4>Results</h4>Synthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology.<h4>Discussion</h4>This multistudy project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy.<h4>Highlights</h4>N(+), C(-), E(-), PA(-), and NA(+) were associated with incident diagnosis. Results were consistent despite self-report versus clinical diagnosis of dementia. Psychological factors were not associated with neuropathology at autopsy. Individuals with higher conscientiousness and no diagnosis had less neuropathology. High C individuals may withstand neuropathology for longer before death."],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis."],"pmcid":["PMC10947984"],"funding_grant_id":["R01 AG015819","P30AG72975","R01 AG082954","RF1 AG067622","R01AG018436","P30 AG010161","R01AG072559","P01AG043362","P01 AG003949","P01 AG043362","P30 AG072975","R01 AG018436","R01 AG072559","P30 AG066444","P30AG010161","R01AG017917","R01 AG017917","R01AG15819","P01 AG003991","P01AG03949","R01AG067622","R01 AG067622"],"pubmed_authors":["Yoneda T","Bennett DA","Hassenstab J","Katz MJ","Graham EK","Lipton RB","Morris J","James BD","Mroczek DK","Beck ED"],"additional_accession":[]},"is_claimable":false,"name":"Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.","description":"<h4>Introduction</h4>The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear.<h4>Methods</h4>Using data from eight independent studies (N<sub>total</sub> = 44,531; N<sub>dementia</sub> = 1703; baseline M<sub>age</sub> = 49 to 81 years, 26 to 61% female; M<sub>follow-up</sub> range = 3.53 to 21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia.<h4>Results</h4>Synthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology.<h4>Discussion</h4>This multistudy project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy.<h4>Highlights</h4>N(+), C(-), E(-), PA(-), and NA(+) were associated with incident diagnosis. Results were consistent despite self-report versus clinical diagnosis of dementia. Psychological factors were not associated with neuropathology at autopsy. Individuals with higher conscientiousness and no diagnosis had less neuropathology. High C individuals may withstand neuropathology for longer before death.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-03-31T11:53:55.607Z","creation":"2025-04-05T22:31:16.808Z"},"accession":"S-EPMC10947984","cross_references":{"pubmed":["38018701"],"doi":["10.1002/alz.13523"]}}