biostudies-literatureBeck EDNIA NIH HHSNational Institutes of HealthNIH HHSNational Institute on Aging1497-1514https://www.ebi.ac.uk/biostudies/studies/S-EPMC10947984biostudies-literatureUnknown20(3)<h4>Introduction</h4>The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear.<h4>Methods</h4>Using data from eight independent studies (N_total = 44,531; N_dementia = 1703; baseline M_age = 49 to 81 years, 26 to 61% female; M_follow-up range = 3.53 to 21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia.<h4>Results</h4>Synthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology.<h4>Discussion</h4>This multistudy project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy.<h4>Highlights</h4>N(+), C(-), E(-), PA(-), and NA(+) were associated with incident diagnosis. Results were consistent despite self-report versus clinical diagnosis of dementia. Psychological factors were not associated with neuropathology at autopsy. Individuals with higher conscientiousness and no diagnosis had less neuropathology. High C individuals may withstand neuropathology for longer before death.Alzheimer's & dementia : the journal of the Alzheimer's AssociationPersonality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.PMC10947984R01 AG015819P30AG72975R01 AG082954RF1 AG067622R01AG018436P30 AG010161R01AG072559P01AG043362P01 AG003949P01 AG043362P30 AG072975R01 AG018436R01 AG072559P30 AG066444P30AG010161R01AG017917R01 AG017917R01AG15819P01 AG003991P01AG03949R01AG067622R01 AG067622Yoneda TBennett DAHassenstab JKatz MJGraham EKLipton RBMorris JJames BDMroczek DKBeck EDfalsePersonality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.<h4>Introduction</h4>The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear.<h4>Methods</h4>Using data from eight independent studies (N_total = 44,531; N_dementia = 1703; baseline M_age = 49 to 81 years, 26 to 61% female; M_follow-up range = 3.53 to 21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia.<h4>Results</h4>Synthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology.<h4>Discussion</h4>This multistudy project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy.<h4>Highlights</h4>N(+), C(-), E(-), PA(-), and NA(+) were associated with incident diagnosis. Results were consistent despite self-report versus clinical diagnosis of dementia. Psychological factors were not associated with neuropathology at autopsy. Individuals with higher conscientiousness and no diagnosis had less neuropathology. High C individuals may withstand neuropathology for longer before death.2024-01-01T00:00:00Z2024 Mar2026-03-31T11:53:55.607Z2025-04-05T22:31:16.808ZS-EPMC109479843801870110.1002/alz.13523