biostudies-literatureLiu KNatural Science Foundation of Hunan Province1264082https://www.ebi.ac.uk/biostudies/studies/S-EPMC10948455biostudies-literatureUnknown12<h4>Background</h4>This study aimed to evaluate the causal impact of common modifiable lifestyles on obstructive sleep apnea (OSA), which is beneficial for recommendations to prevent and manage OSA.<h4>Method</h4>Published genome-wide association study (GWAS) summary statistics were used to perform two-sample Mendelian randomization (MR). Variants associated with each exposure of smoking, drinking, and leisure sedentary behaviors at the genetic level were used as instrumental variables (IVs). Then, inverse-variance weighting (IVW) was considered the primary result for causality. Moreover, several complimented approaches were also included to verify the observed associations. MR-PRESSO and MR-Egger intercept were applied to test the horizontal pleiotropy. To assess heterogeneity, Cochran's Frontiers in public healthEffects of common lifestyle factors on obstructive sleep apnea: precautions in daily life based on causal inferences.PMC10948455No.2023JJ20098; No. 2023JJ50398Liu JLiu KChen ZZhang YYi MHe MLiu BZang CWang JSu XfalseEffects of common lifestyle factors on obstructive sleep apnea: precautions in daily life based on causal inferences.<h4>Background</h4>This study aimed to evaluate the causal impact of common modifiable lifestyles on obstructive sleep apnea (OSA), which is beneficial for recommendations to prevent and manage OSA.<h4>Method</h4>Published genome-wide association study (GWAS) summary statistics were used to perform two-sample Mendelian randomization (MR). Variants associated with each exposure of smoking, drinking, and leisure sedentary behaviors at the genetic level were used as instrumental variables (IVs). Then, inverse-variance weighting (IVW) was considered the primary result for causality. Moreover, several complimented approaches were also included to verify the observed associations. MR-PRESSO and MR-Egger intercept were applied to test the horizontal pleiotropy. To assess heterogeneity, Cochran's 2024-01-01T00:00:00Z20242026-07-15T02:33:13.354Z2026-06-28T03:06:33.935ZS-EPMC109484553850468110.3389/fpubh.2024.1264082