{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Petersen KA"],"funding":["The Wood Next Foundation is a private foundation","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","NIDA NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","Brain and Behavior Research Foundation","NINDS NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"],"pagination":["796-805"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10948754"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(5)"],"pubmed_abstract":["The human striatum can be subdivided into the caudate, putamen, and nucleus accumbens (NAc). In mice, this roughly corresponds to the dorsal medial striatum (DMS), dorsal lateral striatum (DLS), and ventral striatum (NAc). Each of these structures have some overlapping and distinct functions related to motor control, cognitive processing, motivation, and reward. Previously, we used a \"time-of-death\" approach to identify diurnal rhythms in RNA transcripts in these three human striatal subregions. Here, we identify molecular rhythms across similar striatal subregions collected from C57BL/6J mice across 6 times of day and compare results to the human striatum. Pathway analysis indicates a large degree of overlap between species in rhythmic transcripts involved in processes like cellular stress, energy metabolism, and translation. Notably, a striking finding in humans is that small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) are among the most highly rhythmic transcripts in the NAc and this is not conserved in mice, suggesting the rhythmicity of RNA processing in this region could be uniquely human. Furthermore, the peak timing of overlapping rhythmic genes is altered between species, but not consistently in one direction. Taken together, these studies reveal conserved as well as distinct transcriptome rhythms across the human and mouse striatum and are an important step in understanding the normal function of diurnal rhythms in humans and model organisms in these regions and how disruption could lead to pathology."],"journal":["Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],"pubmed_title":["Comparative rhythmic transcriptome profiling of human and mouse striatal subregions."],"pmcid":["PMC10948754"],"funding_grant_id":["DA046346","MH111601","MH106460","R01 MH106460","NS127064","P50 DA046346","T32 NS007433","DA039865","R01 MH111601","MH128763","R21 NS127064","K01 MH128763","R01 DA039865","R01 DA023988","30823"],"pubmed_authors":["Burns JN","Cerwensky AJ","Zong W","Petersen KA","Shankar VG","Scott MR","Tseng GC","Ketchesin KD","McClung CA","Kim SM","Depoy LM"],"additional_accession":[]},"is_claimable":false,"name":"Comparative rhythmic transcriptome profiling of human and mouse striatal subregions.","description":"The human striatum can be subdivided into the caudate, putamen, and nucleus accumbens (NAc). In mice, this roughly corresponds to the dorsal medial striatum (DMS), dorsal lateral striatum (DLS), and ventral striatum (NAc). Each of these structures have some overlapping and distinct functions related to motor control, cognitive processing, motivation, and reward. Previously, we used a \"time-of-death\" approach to identify diurnal rhythms in RNA transcripts in these three human striatal subregions. Here, we identify molecular rhythms across similar striatal subregions collected from C57BL/6J mice across 6 times of day and compare results to the human striatum. Pathway analysis indicates a large degree of overlap between species in rhythmic transcripts involved in processes like cellular stress, energy metabolism, and translation. Notably, a striking finding in humans is that small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) are among the most highly rhythmic transcripts in the NAc and this is not conserved in mice, suggesting the rhythmicity of RNA processing in this region could be uniquely human. Furthermore, the peak timing of overlapping rhythmic genes is altered between species, but not consistently in one direction. Taken together, these studies reveal conserved as well as distinct transcriptome rhythms across the human and mouse striatum and are an important step in understanding the normal function of diurnal rhythms in humans and model organisms in these regions and how disruption could lead to pathology.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-02T06:34:01.633Z","creation":"2026-04-15T03:15:28.43Z"},"accession":"S-EPMC10948754","cross_references":{"pubmed":["38182777"],"doi":["10.1038/s41386-023-01788-w"]}}