biostudies-literatureQing WNatural Science Foundation of Hunan ProvinceNational Natural Science Foundation of China39https://www.ebi.ac.uk/biostudies/studies/S-EPMC10949616biostudies-literatureUnknown82(1)<h4>Background</h4>Midlife obesity is a modifiable risk factor for Alzheimer's disease. However, the association between childhood obesity and Alzheimer's disease remains largely unknown. Therefore, we conducted a mendelian randomization analysis (MR) to assess the causal link between childhood obesity and Alzheimer's disease.<h4>Methods</h4>Using summary statistics from publicly available genome-wide association studies (GWAS) database, we explored the genetic link between childhood obesity and Alzheimer's disease through a two-sample MR. The primary analysis employed the inverse-variance weighted (IVW) method. To complement our findings, we also employed MR-Egger, weighted median, simple model, and weighted model methods for MR estimates. Furthermore, we conducted Cochrane's Q-statistic Archives of public health = Archives belges de sante publiqueChildhood obesity and risk of Alzheimer's disease: a Mendelian randomization study.PMC109496162021JJ4094282301381Qian YQing WfalseChildhood obesity and risk of Alzheimer's disease: a Mendelian randomization study.<h4>Background</h4>Midlife obesity is a modifiable risk factor for Alzheimer's disease. However, the association between childhood obesity and Alzheimer's disease remains largely unknown. Therefore, we conducted a mendelian randomization analysis (MR) to assess the causal link between childhood obesity and Alzheimer's disease.<h4>Methods</h4>Using summary statistics from publicly available genome-wide association studies (GWAS) database, we explored the genetic link between childhood obesity and Alzheimer's disease through a two-sample MR. The primary analysis employed the inverse-variance weighted (IVW) method. To complement our findings, we also employed MR-Egger, weighted median, simple model, and weighted model methods for MR estimates. Furthermore, we conducted Cochrane's Q-statistic 2024-01-01T00:00:00Z2024 Mar2026-06-03T05:05:12.404Z2024-11-15T04:03:21.334ZS-EPMC109496163850022010.1186/s13690-024-01271-y