{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dou DR"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","Howard Hughes Medical Institute","Scleroderma Research Foundation","NIAMS NIH HHS","NIH","Kao Corporation"],"pagination":["733-749.e16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10949934"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["187(3)"],"pubmed_abstract":["Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) is expressed only in females to randomly inactivate one of the two X chromosomes to achieve gene dosage compensation. Here, we show that the Xist ribonucleoprotein (RNP) complex comprising numerous autoantigenic components is an important driver of sex-biased autoimmunity. Inducible transgenic expression of a non-silencing form of Xist in male mice introduced Xist RNP complexes and sufficed to produce autoantibodies. Male SJL/J mice expressing transgenic Xist developed more severe multi-organ pathology in a pristane-induced lupus model than wild-type males. Xist expression in males reprogrammed "],"journal":["Cell"],"pubmed_title":["Xist ribonucleoproteins promote female sex-biased autoimmunity."],"pmcid":["PMC10949934"],"funding_grant_id":["R01 AR069572","K99 AR080218","T32 AR007422","R01-AR069572","K99/R00","T32 AR050942"],"pubmed_authors":["Belk JA","Chung LS","Chang HY","Shah AA","Petri M","Chen DC","Li R","Chang S","Lundberg EK","Fiorentino DF","Zhao Y","Feng A","Abe BT","Kraft K","Yu B","Casey KM","Hellstrom C","Srinivasan S","Wutz A","Utz PJ","Goldman DW","Sjoberg R","Dou DR"],"additional_accession":[]},"is_claimable":false,"name":"Xist ribonucleoproteins promote female sex-biased autoimmunity.","description":"Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) is expressed only in females to randomly inactivate one of the two X chromosomes to achieve gene dosage compensation. Here, we show that the Xist ribonucleoprotein (RNP) complex comprising numerous autoantigenic components is an important driver of sex-biased autoimmunity. Inducible transgenic expression of a non-silencing form of Xist in male mice introduced Xist RNP complexes and sufficed to produce autoantibodies. Male SJL/J mice expressing transgenic Xist developed more severe multi-organ pathology in a pristane-induced lupus model than wild-type males. Xist expression in males reprogrammed ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-01T14:39:56.513Z","creation":"2025-04-03T23:22:35.937Z"},"accession":"S-EPMC10949934","cross_references":{"pubmed":["38306984"],"doi":["10.1016/j.cell.2023.12.037"]}}