{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Epps KC"],"funding":["NCATS NIH HHS","NIA NIH HHS","NHLBI NIH HHS"],"pagination":["100978"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10950300"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(5)"],"pubmed_abstract":["<h4>Background</h4>Little is known about sex-related differences in outcomes of patients with cardiogenic shock (CS) treated within a standardized team-based approach (STBA).<h4>Methods</h4>We evaluated 520 consecutive patients (151 women and 369 men) with CS due to acute myocardial infarction (AMI) and heart failure (HF) in a single-center registry (January 2017-December 2019) and examined outcomes according to sex and CS phenotype. The primary outcome was in-hospital mortality. Secondary outcomes included major adverse cardiac events, 30-day mortality, major bleeding, vascular complications, and stroke.<h4>Results</h4>Women with AMI-CS had higher baseline acuity (CardShock score: female [F]: 5.5 vs male [M]: 4.0; <i>P</i> = .04). Women with HF-CS more often presented with cardiac arrest (F: 12.4% vs M: 2.4%; <i>P</i>< .01) and had higher rates of vasopressor use (F: 70.8% vs M: 58.0%; <i>P</i> = .04) and mechanical circulatory support (F: 46.1% vs M: 32.5%; <i>P</i> = .04). There were no sex-related differences in in-hospital mortality for AMI-CS (F: 45.2% vs M: 36.9%; <i>P</i> = .28) and HF-CS (F: 28.1% vs M: 24.5%; <i>P</i> = .56). Women with HF-CS experienced higher rates of major bleeding (F: 25.8% vs M: 13.7%; <i>P</i> = .02) and vascular complications (F: 15.7% vs M: 6.1%; <i>P</i> = .01). However, female sex was not an independent predictor of these complications. No sex differences in survival were noted at 1 year.<h4>Conclusions</h4>Within an STBA, although women with AMI-CS and HF-CS presented with higher acuity, they experienced similar in-hospital mortality, major adverse cardiac events, 30-day mortality, stroke, and 30-day readmissions as men. Further research is needed to better understand the extent to which historical differences in CS outcomes can be mitigated by an STBA."],"journal":["Journal of the Society for Cardiovascular Angiography & Interventions"],"pubmed_title":["Sex-Related Differences in Patient Characteristics, Hemodynamics, and Outcomes of Cardiogenic Shock: INOVA-SHOCK Registry."],"pmcid":["PMC10950300"],"funding_grant_id":["UL1 TR003015","R01 HL151293","P30 AG021334","R01 AG078153","R21 AG072095","K23 HL153771","R01 HL154768"],"pubmed_authors":["Sherwood MW","Epps KC","Psotka M","Sinha SS","Truesdell AG","deFilippi C","Rosner C","Tang D","Desai S","Raja A","Batchelor W","Tehrani BN","Damluji AA","Cotugno A","O'Connor C","Singh R","Ibrahim N","Bagchi P"],"additional_accession":[]},"is_claimable":false,"name":"Sex-Related Differences in Patient Characteristics, Hemodynamics, and Outcomes of Cardiogenic Shock: INOVA-SHOCK Registry.","description":"<h4>Background</h4>Little is known about sex-related differences in outcomes of patients with cardiogenic shock (CS) treated within a standardized team-based approach (STBA).<h4>Methods</h4>We evaluated 520 consecutive patients (151 women and 369 men) with CS due to acute myocardial infarction (AMI) and heart failure (HF) in a single-center registry (January 2017-December 2019) and examined outcomes according to sex and CS phenotype. The primary outcome was in-hospital mortality. Secondary outcomes included major adverse cardiac events, 30-day mortality, major bleeding, vascular complications, and stroke.<h4>Results</h4>Women with AMI-CS had higher baseline acuity (CardShock score: female [F]: 5.5 vs male [M]: 4.0; <i>P</i> = .04). Women with HF-CS more often presented with cardiac arrest (F: 12.4% vs M: 2.4%; <i>P</i>< .01) and had higher rates of vasopressor use (F: 70.8% vs M: 58.0%; <i>P</i> = .04) and mechanical circulatory support (F: 46.1% vs M: 32.5%; <i>P</i> = .04). There were no sex-related differences in in-hospital mortality for AMI-CS (F: 45.2% vs M: 36.9%; <i>P</i> = .28) and HF-CS (F: 28.1% vs M: 24.5%; <i>P</i> = .56). Women with HF-CS experienced higher rates of major bleeding (F: 25.8% vs M: 13.7%; <i>P</i> = .02) and vascular complications (F: 15.7% vs M: 6.1%; <i>P</i> = .01). However, female sex was not an independent predictor of these complications. No sex differences in survival were noted at 1 year.<h4>Conclusions</h4>Within an STBA, although women with AMI-CS and HF-CS presented with higher acuity, they experienced similar in-hospital mortality, major adverse cardiac events, 30-day mortality, stroke, and 30-day readmissions as men. Further research is needed to better understand the extent to which historical differences in CS outcomes can be mitigated by an STBA.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep-Oct","modification":"2025-04-04T20:07:17.345Z","creation":"2025-04-04T20:07:17.345Z"},"accession":"S-EPMC10950300","cross_references":{"pubmed":["38504778"],"doi":["10.1016/j.jscai.2023.100978"]}}