biostudies-literatureUnknown9(2)Wang RNational Key Research and Development Program of China Stem Cell and Translational ResearchNational Natural Science Foundation of ChinaNational Health and Medical Research CouncilThe epicardium provides epicardial-derived cells and molecular signals to support cardiac development and regeneration. Zebrafish and mouse studies have shown that <i>ccm2</i>, a cerebral cavernous malformation disease gene, is essential for cardiac development. Endocardial cell-specific deletion of <i>Ccm2</i> in mice has previously established that Ccm2 is essential for maintenance of the cardiac jelly for cardiac development during early gestation. The current study aimed to explore the function of Ccm2 in epicardial cells for heart development and regeneration. Through genetic deletion of <i>Ccm2</i> in epicardial cells, our in vivo and ex vivo experiments revealed that <i>Ccm2</i> is required by epicardial cells to support heart development. Ccm2 regulates epicardial cell adhesion, ceJACC. Basic to translational science203-219https://www.ebi.ac.uk/biostudies/studies/S-EPMC10950406biostudies-literatureEpicardial CCM2 Promotes Cardiac Development and Repair Via its Regulation on Cytoskeletal Reorganization.PMC10950406Yang XZheng XWang RSong RZhao QLu DLiu RWang XWu STDu LWong JXu ZfalseEpicardial CCM2 Promotes Cardiac Development and Repair Via its Regulation on Cytoskeletal Reorganization.The epicardium provides epicardial-derived cells and molecular signals to support cardiac development and regeneration. Zebrafish and mouse studies have shown that <i>ccm2</i>, a cerebral cavernous malformation disease gene, is essential for cardiac development. Endocardial cell-specific deletion of <i>Ccm2</i> in mice has previously established that Ccm2 is essential for maintenance of the cardiac jelly for cardiac development during early gestation. The current study aimed to explore the function of Ccm2 in epicardial cells for heart development and regeneration. Through genetic deletion of <i>Ccm2</i> in epicardial cells, our in vivo and ex vivo experiments revealed that <i>Ccm2</i> is required by epicardial cells to support heart development. Ccm2 regulates epicardial cell adhesion, ce2024-01-01T00:00:00Z2024 Feb2025-04-18T19:27:05.537Z2025-04-07T07:10:58.39ZS-EPMC109504063851071610.1016/j.jacbts.2023.09.004