biostudies-literatureZhang YNational Institute of Environmental Health SciencesNIEHS NIH HHS123513https://www.ebi.ac.uk/biostudies/studies/S-EPMC10950513biostudies-literatureUnknown346Per- and polyfluoroalkyl substances (PFAS) exposure was associated with changes in thyroid function in pregnant mothers and the general population. Limited such evidence exists in other susceptible populations such as females with fertility problems. This cross-sectional study included 287 females seeking medically assisted reproduction at a fertility clinic in Massachusetts, United States, between 2005 and 2019. Six long-alkyl chain PFAS, thyroid hormones, and autoimmune antibodies were quantified in baseline serum samples. We used generalized linear models and quantile g-computation to evaluate associations of individual PFAS and their total mixture with thyroid biomarkers. Most females were White individuals (82.7%), had graduate degrees (57.8%), and nearly half had unexplained subfertiEnvironmental pollution (Barking, Essex : 1987)Association between per- and polyfluoroalkyl substances exposure and thyroid function biomarkers among females attending a fertility clinic.PMC10950513T32 ES007069R01 ES031657R01ES031657Mustieles VFirst OTorres NKorevaar TIMCoburn-Sanderson ASun YBroeren MACMesserlian CMartin LPetrozza JCBotelho JCZhang YCalafat AMBibi ZWang YXSouter IfalseAssociation between per- and polyfluoroalkyl substances exposure and thyroid function biomarkers among females attending a fertility clinic.Per- and polyfluoroalkyl substances (PFAS) exposure was associated with changes in thyroid function in pregnant mothers and the general population. Limited such evidence exists in other susceptible populations such as females with fertility problems. This cross-sectional study included 287 females seeking medically assisted reproduction at a fertility clinic in Massachusetts, United States, between 2005 and 2019. Six long-alkyl chain PFAS, thyroid hormones, and autoimmune antibodies were quantified in baseline serum samples. We used generalized linear models and quantile g-computation to evaluate associations of individual PFAS and their total mixture with thyroid biomarkers. Most females were White individuals (82.7%), had graduate degrees (57.8%), and nearly half had unexplained subferti2024-01-01T00:00:00Z2024 Apr2025-06-28T03:05:18.922Z2025-06-28T03:05:18.922ZS-EPMC109505133835053410.1016/j.envpol.2024.123513