biostudies-literatureYang HAmerican Heart AssociationRadiological Society of North AmericaNIBIB NIH HHSNHLBI NIH HHSNational Institutes of HealthNIH HHS1965-1977https://www.ebi.ac.uk/biostudies/studies/S-EPMC10950531biostudies-literatureUnknown91(5)<h4>Purpose</h4>To develop a highly-accelerated, real-time phase contrast (rtPC) MRI pulse sequence with 40 fps frame rate (25 ms effective temporal resolution).<h4>Methods</h4>Highly-accelerated golden-angle radial sparse parallel (GRASP) with over regularization may result in temporal blurring, which in turn causes underestimation of peak velocity. Thus, we amplified GRASP performance by synergistically combining view-sharing (VS) and k-space weighted image contrast (KWIC) filtering. In 17 pediatric patients with congenital heart disease (CHD), the conventional GRASP and the proposed GRASP amplified by VS and KWIC (or GRASP + VS + KWIC) reconstruction for rtPC MRI were compared with respect to clinical standard PC MRI in measuring hemodynamic parameters (peak velocity, forward volume, baMagnetic resonance in medicineGRASP reconstruction amplified with view-sharing and KWIC filtering reduces underestimation of peak velocity in highly-accelerated real-time phase-contrast MRI: A preliminary evaluation in pediatric patients with congenital heart disease.PMC10950531949899R01HL116895R01HL167148R01 HL15107923PRE1027440R01HL151079F31 HL165915R21EB030806R01 HL116895F31HL165915R21 EB030806R01 HL167148EILTC230219IPLOI34760317Yang HKim DLarsen AMarkl MRobinson JDBaraboo JJHong KFan LRigsby CKfalseGRASP reconstruction amplified with view-sharing and KWIC filtering reduces underestimation of peak velocity in highly-accelerated real-time phase-contrast MRI: A preliminary evaluation in pediatric patients with congenital heart disease.<h4>Purpose</h4>To develop a highly-accelerated, real-time phase contrast (rtPC) MRI pulse sequence with 40 fps frame rate (25 ms effective temporal resolution).<h4>Methods</h4>Highly-accelerated golden-angle radial sparse parallel (GRASP) with over regularization may result in temporal blurring, which in turn causes underestimation of peak velocity. Thus, we amplified GRASP performance by synergistically combining view-sharing (VS) and k-space weighted image contrast (KWIC) filtering. In 17 pediatric patients with congenital heart disease (CHD), the conventional GRASP and the proposed GRASP amplified by VS and KWIC (or GRASP + VS + KWIC) reconstruction for rtPC MRI were compared with respect to clinical standard PC MRI in measuring hemodynamic parameters (peak velocity, forward volume, ba2024-01-01T00:00:00Z2024 May2025-07-12T03:04:25.201Z2025-07-12T03:04:25.201ZS-EPMC109505313808439710.1002/mrm.29974