{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45"],"submitter":["Zheng Y"],"pubmed_abstract":["<h4>Background</h4>The musculoskeletal system contains an extensive network of lymphatic vessels. Decreased lymph flow of the draining collecting lymphatics usually occurs in clinic after traumatic fractures. However, whether defects in lymphatic drainage can affect fracture healing is unclear.<h4>Methods</h4>To investigate the effect of lymphatic dysfunction on fracture healing, we used a selective VEGFR3 tyrosine kinase inhibitor to treat tibial fractured mice for 5 weeks versus a vehicle-treated control. To ensure successfully establishing deceased lymphatic drainage model for fractured mice, we measured lymphatic clearance by near infrared indocyanine green lymphatic imaging (NIR-ICG) and the volume of the draining popliteal lymph nodes (PLNs) by ultrasound at the whole phases of fract"],"journal":["Journal of orthopaedic translation"],"pagination":["66-74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10950565"],"repository":["biostudies-literature"],"pubmed_title":["A novel therapy for fracture healing by increasing lymphatic drainage."],"pmcid":["PMC10950565"],"pubmed_authors":["Zheng Y","Wang P","Zhao L","Xing L","Shi Q","Xu H","Wang Y","Zhao Y","Liang Q","Li N"],"additional_accession":[]},"is_claimable":false,"name":"A novel therapy for fracture healing by increasing lymphatic drainage.","description":"<h4>Background</h4>The musculoskeletal system contains an extensive network of lymphatic vessels. Decreased lymph flow of the draining collecting lymphatics usually occurs in clinic after traumatic fractures. However, whether defects in lymphatic drainage can affect fracture healing is unclear.<h4>Methods</h4>To investigate the effect of lymphatic dysfunction on fracture healing, we used a selective VEGFR3 tyrosine kinase inhibitor to treat tibial fractured mice for 5 weeks versus a vehicle-treated control. To ensure successfully establishing deceased lymphatic drainage model for fractured mice, we measured lymphatic clearance by near infrared indocyanine green lymphatic imaging (NIR-ICG) and the volume of the draining popliteal lymph nodes (PLNs) by ultrasound at the whole phases of fract","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-18T14:12:40.351Z","creation":"2025-04-07T00:15:52.781Z"},"accession":"S-EPMC10950565","cross_references":{"pubmed":["38511124"],"doi":["10.1016/j.jot.2024.02.001"]}}