biostudies-literatureUnknown102Li GWuxi City Department of Science and Technology<h4>Background</h4>Chemoresistance is a critical factor contributing to poor prognosis in clinical patients with cancer undergoing postoperative adjuvant chemotherapy. The role of gut microbiota in mediating resistance to tumour chemotherapy remains to be investigated.<h4>Methods</h4>Patients with CRC were categorised into clinical benefit responders (CBR) and no clinical benefit responders (NCB) based on chemotherapy efficacy. Differential bacterial analysis using 16S rRNA sequencing revealed Desulfovibrio as a distinct microbe between the two groups. Employing a syngeneic transplantation model, we assessed the effect of Desulfovibrio on chemotherapy by measuring tumour burden, weight, and Ki-67 expression. We further explored the mechanisms underlying the compromised chemotherapeutic effEBioMedicine105041https://www.ebi.ac.uk/biostudies/studies/S-EPMC10950750biostudies-literatureDesulfovibrio desulfuricans and its derived metabolites confer resistance to FOLFOX through METTL3.PMC10950750Li GLiu HWang QWang FYan YYang CMao YYu YfalseDesulfovibrio desulfuricans and its derived metabolites confer resistance to FOLFOX through METTL3.<h4>Background</h4>Chemoresistance is a critical factor contributing to poor prognosis in clinical patients with cancer undergoing postoperative adjuvant chemotherapy. The role of gut microbiota in mediating resistance to tumour chemotherapy remains to be investigated.<h4>Methods</h4>Patients with CRC were categorised into clinical benefit responders (CBR) and no clinical benefit responders (NCB) based on chemotherapy efficacy. Differential bacterial analysis using 16S rRNA sequencing revealed Desulfovibrio as a distinct microbe between the two groups. Employing a syngeneic transplantation model, we assessed the effect of Desulfovibrio on chemotherapy by measuring tumour burden, weight, and Ki-67 expression. We further explored the mechanisms underlying the compromised chemotherapeutic eff2024-01-01T00:00:00Z2024 Apr2026-07-14T23:42:45.364Z2025-04-05T22:29:49.74ZS-EPMC109507503848455510.1016/j.ebiom.2024.105041