biostudies-literatureJaffery HVersus ArthritisWellcome Trust2148-2160https://www.ebi.ac.uk/biostudies/studies/S-EPMC10952620biostudies-literatureUnknown75(12)<h4>Objective</h4>IĸB protein B cell lymphoma 3-encoded protein (BCL3) is a regulator of the NF-κB family of transcription factors. NF-κB signaling fundamentally influences the fate of bone-forming osteoblasts and bone-resorbing osteoclasts, but the role of BCL3 in bone biology has not been investigated. The objective of this study was to evaluate BCL3 in skeletal development, maintenance, and osteoarthritic pathology.<h4>Methods</h4>To assess the contribution of BCL3 to skeletal homeostasis, neonatal mice (n = 6-14) lacking BCL3 (Bcl3^-/- ) and wild-type (WT) controls were characterized for bone phenotype and density. To reveal the contribution to bone phenotype by the osteoblast compartment in Bcl3^-/- mice, transcriptomic analysis of early osteogenic differentiation Arthritis & rheumatology (Hoboken, N.J.)IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health.PMC10952620099786/Z/12/A2207222858099786/Z/12/ZMcInnes IBvan 't Hof RJJaffery HHuesa CChilaka SDoonan JAkbar MDunning LCarmody RJGoodyear CSCole JTanner KEfalseIĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health.<h4>Objective</h4>IĸB protein B cell lymphoma 3-encoded protein (BCL3) is a regulator of the NF-κB family of transcription factors. NF-κB signaling fundamentally influences the fate of bone-forming osteoblasts and bone-resorbing osteoclasts, but the role of BCL3 in bone biology has not been investigated. The objective of this study was to evaluate BCL3 in skeletal development, maintenance, and osteoarthritic pathology.<h4>Methods</h4>To assess the contribution of BCL3 to skeletal homeostasis, neonatal mice (n = 6-14) lacking BCL3 (Bcl3^-/- ) and wild-type (WT) controls were characterized for bone phenotype and density. To reveal the contribution to bone phenotype by the osteoblast compartment in Bcl3^-/- mice, transcriptomic analysis of early osteogenic differentiation 2023-01-01T00:00:00Z2023 Dec2026-06-02T19:53:57.289Z2024-11-20T03:29:23.011ZS-EPMC109526203741075410.1002/art.42639