{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ying L"],"funding":["Public Health Agency of Canada","Tanoto Foundation","U.S. Department of Defense","National Health and Medical Research Council","National Medical Research Council"],"pagination":["402-414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10952994"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["259(4)"],"pubmed_abstract":["Mucosa-associated lymphoid tissue (MALT) lymphoma is a B-cell tumour that develops over many decades in the stomachs of individuals with chronic Helicobacter pylori infection. We developed a new mouse model of human gastric MALT lymphoma in which mice with a myeloid-specific deletion of the innate immune molecule, Nlrc5, develop precursor B-cell lesions to MALT lymphoma at only 3 months post-Helicobacter infection versus 9-24 months in existing models. The gastric B-cell lesions in the Nlrc5 knockout mice had the histopathological features of the human disease, notably lymphoepithelial-like lesions, centrocyte-like cells, and were infiltrated by dendritic cells (DCs), macrophages, and T-cells (CD4<sup>+</sup> , CD8<sup>+</sup> and Foxp3<sup>+</sup> ). Mouse and human gastric tissues contai"],"journal":["The Journal of pathology"],"pubmed_title":["Anti-CD40L therapy prevents the formation of precursor lesions to gastric B-cell MALT lymphoma in a mouse model."],"pmcid":["PMC10952994"],"funding_grant_id":["APP2012620","W81XWH‐17‐1‐0606","APP1079904","NMRC‐OFLCG‐18May0028","APP1107930"],"pubmed_authors":["Tran LS","Yu L","Xu P","Ferrero RL","Liu P","Ong CK","Ying L","Cheah DM","Philpott DJ","Lim ST","Ding Z","Colon N","Emery J","Tu Y","Cheng CL","Wray-McCann G","Le LH"],"additional_accession":[]},"is_claimable":false,"name":"Anti-CD40L therapy prevents the formation of precursor lesions to gastric B-cell MALT lymphoma in a mouse model.","description":"Mucosa-associated lymphoid tissue (MALT) lymphoma is a B-cell tumour that develops over many decades in the stomachs of individuals with chronic Helicobacter pylori infection. We developed a new mouse model of human gastric MALT lymphoma in which mice with a myeloid-specific deletion of the innate immune molecule, Nlrc5, develop precursor B-cell lesions to MALT lymphoma at only 3 months post-Helicobacter infection versus 9-24 months in existing models. The gastric B-cell lesions in the Nlrc5 knockout mice had the histopathological features of the human disease, notably lymphoepithelial-like lesions, centrocyte-like cells, and were infiltrated by dendritic cells (DCs), macrophages, and T-cells (CD4<sup>+</sup> , CD8<sup>+</sup> and Foxp3<sup>+</sup> ). Mouse and human gastric tissues contai","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-22T13:02:42.03Z","creation":"2024-11-15T04:02:29.696Z"},"accession":"S-EPMC10952994","cross_references":{"pubmed":["36640261"],"doi":["10.1002/path.6053"]}}