biostudies-literatureYing LPublic Health Agency of CanadaTanoto FoundationU.S. Department of DefenseNational Health and Medical Research CouncilNational Medical Research Council402-414https://www.ebi.ac.uk/biostudies/studies/S-EPMC10952994biostudies-literatureUnknown259(4)Mucosa-associated lymphoid tissue (MALT) lymphoma is a B-cell tumour that develops over many decades in the stomachs of individuals with chronic Helicobacter pylori infection. We developed a new mouse model of human gastric MALT lymphoma in which mice with a myeloid-specific deletion of the innate immune molecule, Nlrc5, develop precursor B-cell lesions to MALT lymphoma at only 3 months post-Helicobacter infection versus 9-24 months in existing models. The gastric B-cell lesions in the Nlrc5 knockout mice had the histopathological features of the human disease, notably lymphoepithelial-like lesions, centrocyte-like cells, and were infiltrated by dendritic cells (DCs), macrophages, and T-cells (CD4⁺ , CD8⁺ and Foxp3⁺ ). Mouse and human gastric tissues contaiThe Journal of pathologyAnti-CD40L therapy prevents the formation of precursor lesions to gastric B-cell MALT lymphoma in a mouse model.PMC10952994APP2012620W81XWH‐17‐1‐0606APP1079904NMRC‐OFLCG‐18May0028APP1107930Tran LSYu LXu PFerrero RLLiu POng CKYing LCheah DMPhilpott DJLim STDing ZColon NEmery JTu YCheng CLWray-McCann GLe LHfalseAnti-CD40L therapy prevents the formation of precursor lesions to gastric B-cell MALT lymphoma in a mouse model.Mucosa-associated lymphoid tissue (MALT) lymphoma is a B-cell tumour that develops over many decades in the stomachs of individuals with chronic Helicobacter pylori infection. We developed a new mouse model of human gastric MALT lymphoma in which mice with a myeloid-specific deletion of the innate immune molecule, Nlrc5, develop precursor B-cell lesions to MALT lymphoma at only 3 months post-Helicobacter infection versus 9-24 months in existing models. The gastric B-cell lesions in the Nlrc5 knockout mice had the histopathological features of the human disease, notably lymphoepithelial-like lesions, centrocyte-like cells, and were infiltrated by dendritic cells (DCs), macrophages, and T-cells (CD4⁺ , CD8⁺ and Foxp3⁺ ). Mouse and human gastric tissues contai2023-01-01T00:00:00Z2023 Apr2025-04-22T13:02:42.03Z2024-11-15T04:02:29.696ZS-EPMC109529943664026110.1002/path.6053