{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["52(2)"],"submitter":["Pantke A"],"funding":["Robert Koch-Institut"],"pubmed_abstract":["<h4>Purpose</h4>This study examined the characteristics, incidence and prognostic factors of the first AIDS-defining condition developed after more than one year of continuous antiretroviral therapy (ART) among people living with HIV (PLHIV).<h4>Methods</h4>We used data from two multicentre observational cohorts of PLHIV in Germany between 1999 and 2018. Our outcome was the first AIDS-defining event that occurred during follow-up after more than one year of continuous ART. Descriptive analyses at ART initiation, at the time of the AIDS event and of the most frequently observed types of AIDS-defining illnesses were performed. We calculated the incidence rate (IR) per 1000 person-years (PY) and used a bootstrap stepwise selection procedure to identify predictors of the outcome.<h4>Results</h"],"journal":["Infection"],"pagination":["637-648"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10954987"],"repository":["biostudies-literature"],"pubmed_title":["AIDS-defining events among people living with HIV who have been under continuous antiretroviral therapy for more than one year, a German cohort study 1999-2018."],"pmcid":["PMC10954987"],"pubmed_authors":["HIV-1 Seroconverter Cohort and the ClinSurv HIV Cohort","Bruhy M","Hoffmann C","Guler C","Weinberg G","Grunwald S","Schurmann D","Sabranski M","Schubel N","Trautmann S","Stephan C","Berger A","Kollan C","Degen O","Claus B","Teichmann D","Kuhlendahl F","Pletz MW","Fatkenheuer G","Scholten S","Buhk T","Vogelmann R","Hower M","Schafer G","Grunewald T","Schewe K","Schleenvoigt BT","Mainka A","Fischer K","Claus JA","Panstruga P","Bohr U","Rieke A","Thomas C","Hass S","Baumann R","Kurth T","Schranz D","Bogner J","Esser S","Behrens G","Glaunsinger T","Jensen BO","Traidl-Hoffmann C","Ebert MP","Fenske S","Muck B","Gunsenheimer-Bartmeyer B","Gumprecht J","Stoll M","Oette M","Weidemann J","Stellbrink HJ","Lange D","Wesselmann H","Trauth J","Marquardt S","Haberl A","Radzuweit D","Spinner CD","Koppe U","Koppe S","Schneider J","Warncke M","Brockmeyer NH","Deutschinoff G","Schott P","Audebert F","Lindemann S","Rausch M","Pullen O","Bachmann C","Muller M","Harter G","Weninger B","Sonntag B","Adam A","Karcher H","Feind C","Galle PR","Schroder R","Menner N","Kreft B","Vallee M","Kreckel P","Schulbin H","Reineke T","Usadel S","Beider R","Vehreschild JJ","Schoor S","Wasmuth JC","Hamacher L","Jessen H","Hartikainen J","Huttig F","Scheiter R","Bremer V","Arasteh K","Gruner B","Brand S","Roßler S","Berning C","Potthoff A","Spornraft-Ragaller P","Roll C","Biemann L","Arbter PA","Hillenbrand H","Schnaitmann E","Fritzsche C","Todorova A","Rockstroh J","van Bremen K","Grimm R","Lorenzen T","Schenk-Westkamp P","Wiemer D","Jessen AB","Rittweger M","Trein A","Rickassel C","Plettenberg A","Chavez-Valladares A","Pauli R","Knechten H","Schneeweiß S","Hansen S","Gerschmann S","Cordes C","Pantke A","Nicksch L","Sprinzl M","Horst HA","Ruck I","Hellerer U"],"additional_accession":[]},"is_claimable":false,"name":"AIDS-defining events among people living with HIV who have been under continuous antiretroviral therapy for more than one year, a German cohort study 1999-2018.","description":"<h4>Purpose</h4>This study examined the characteristics, incidence and prognostic factors of the first AIDS-defining condition developed after more than one year of continuous antiretroviral therapy (ART) among people living with HIV (PLHIV).<h4>Methods</h4>We used data from two multicentre observational cohorts of PLHIV in Germany between 1999 and 2018. Our outcome was the first AIDS-defining event that occurred during follow-up after more than one year of continuous ART. Descriptive analyses at ART initiation, at the time of the AIDS event and of the most frequently observed types of AIDS-defining illnesses were performed. We calculated the incidence rate (IR) per 1000 person-years (PY) and used a bootstrap stepwise selection procedure to identify predictors of the outcome.<h4>Results</h","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-07-15T02:16:58.808Z","creation":"2025-05-29T21:51:51.386Z"},"accession":"S-EPMC10954987","cross_references":{"pubmed":["38381307"],"doi":["10.1007/s15010-024-02188-y"]}}