biostudies-literatureUnknown52(2)Pantke ARobert Koch-Institut<h4>Purpose</h4>This study examined the characteristics, incidence and prognostic factors of the first AIDS-defining condition developed after more than one year of continuous antiretroviral therapy (ART) among people living with HIV (PLHIV).<h4>Methods</h4>We used data from two multicentre observational cohorts of PLHIV in Germany between 1999 and 2018. Our outcome was the first AIDS-defining event that occurred during follow-up after more than one year of continuous ART. Descriptive analyses at ART initiation, at the time of the AIDS event and of the most frequently observed types of AIDS-defining illnesses were performed. We calculated the incidence rate (IR) per 1000 person-years (PY) and used a bootstrap stepwise selection procedure to identify predictors of the outcome.<h4>Results</hInfection637-648https://www.ebi.ac.uk/biostudies/studies/S-EPMC10954987biostudies-literatureAIDS-defining events among people living with HIV who have been under continuous antiretroviral therapy for more than one year, a German cohort study 1999-2018.PMC10954987HIV-1 Seroconverter Cohort and the ClinSurv HIV CohortBruhy MHoffmann CGuler CWeinberg GGrunwald SSchurmann DSabranski MSchubel NTrautmann SStephan CBerger AKollan CDegen OClaus BTeichmann DKuhlendahl FPletz MWFatkenheuer GScholten SBuhk TVogelmann RHower MSchafer GGrunewald TSchewe KSchleenvoigt BTMainka AFischer KClaus JAPanstruga PBohr URieke AThomas CHass SBaumann RKurth TSchranz DBogner JEsser SBehrens GGlaunsinger TJensen BOTraidl-Hoffmann CEbert MPFenske SMuck BGunsenheimer-Bartmeyer BGumprecht JStoll MOette MWeidemann JStellbrink HJLange DWesselmann HTrauth JMarquardt SHaberl ARadzuweit DSpinner CDKoppe UKoppe SSchneider JWarncke MBrockmeyer NHDeutschinoff GSchott PAudebert FLindemann SRausch MPullen OBachmann CMuller MHarter GWeninger BSonntag BAdam AKarcher HFeind CGalle PRSchroder RMenner NKreft BVallee MKreckel PSchulbin HReineke TUsadel SBeider RVehreschild JJSchoor SWasmuth JCHamacher LJessen HHartikainen JHuttig FScheiter RBremer VArasteh KGruner BBrand SRoßler SBerning CPotthoff ASpornraft-Ragaller PRoll CBiemann LArbter PAHillenbrand HSchnaitmann EFritzsche CTodorova ARockstroh Jvan Bremen KGrimm RLorenzen TSchenk-Westkamp PWiemer DJessen ABRittweger MTrein ARickassel CPlettenberg AChavez-Valladares APauli RKnechten HSchneeweiß SHansen SGerschmann SCordes CPantke ANicksch LSprinzl MHorst HARuck IHellerer UfalseAIDS-defining events among people living with HIV who have been under continuous antiretroviral therapy for more than one year, a German cohort study 1999-2018.<h4>Purpose</h4>This study examined the characteristics, incidence and prognostic factors of the first AIDS-defining condition developed after more than one year of continuous antiretroviral therapy (ART) among people living with HIV (PLHIV).<h4>Methods</h4>We used data from two multicentre observational cohorts of PLHIV in Germany between 1999 and 2018. Our outcome was the first AIDS-defining event that occurred during follow-up after more than one year of continuous ART. Descriptive analyses at ART initiation, at the time of the AIDS event and of the most frequently observed types of AIDS-defining illnesses were performed. We calculated the incidence rate (IR) per 1000 person-years (PY) and used a bootstrap stepwise selection procedure to identify predictors of the outcome.<h4>Results</h2024-01-01T00:00:00Z2024 Apr2026-07-15T02:16:58.808Z2025-05-29T21:51:51.386ZS-EPMC109549873838130710.1007/s15010-024-02188-y