{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Reinehr S"],"pubmed_abstract":["Background
The neurodegenerative processes leading to glaucoma are complex. In addition to elevated intraocular pressure (IOP), an involvement of immunological mechanisms is most likely. In the new multifactorial glaucoma model, a combination of high IOP and optic nerve antigen (ONA) immunization leads to an enhanced loss of retinal ganglion cells accompanied by a higher number of microglia/macrophages in the inner retina. Here, we aimed to evaluate the immune response in this new model, especially the complement activation and the number of T-cells, for the first time. Further, the microglia/macrophage response was examined in more detail.Methods
Six-week-old wildtype (WT+ONA) and βB1-connective tissue growth factor high-pressure mice (CTGF+ONA) were immunized with 1 mg ON"],"journal":["Frontiers in immunology"],"pagination":["1296178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10955086"],"repository":["biostudies-literature"],"pubmed_title":["In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced."],"pmcid":["PMC10955086"],"pubmed_authors":["Theile J","Dick HB","Schulte KK","Joachim SC","Wulf J","Fuchshofer R","Peters M","Reinehr S"],"additional_accession":[]},"is_claimable":false,"name":"In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced.","description":"Background
The neurodegenerative processes leading to glaucoma are complex. In addition to elevated intraocular pressure (IOP), an involvement of immunological mechanisms is most likely. In the new multifactorial glaucoma model, a combination of high IOP and optic nerve antigen (ONA) immunization leads to an enhanced loss of retinal ganglion cells accompanied by a higher number of microglia/macrophages in the inner retina. Here, we aimed to evaluate the immune response in this new model, especially the complement activation and the number of T-cells, for the first time. Further, the microglia/macrophage response was examined in more detail.Methods
Six-week-old wildtype (WT+ONA) and βB1-connective tissue growth factor high-pressure mice (CTGF+ONA) were immunized with 1 mg ON","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-19T05:48:48.623Z","creation":"2024-11-13T04:47:09.705Z"},"accession":"S-EPMC10955086","cross_references":{"pubmed":["38515755"],"doi":["10.3389/fimmu.2024.1296178"]}}