{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Zhang J"],"pubmed_abstract":["Guipi wan (GPW) is a traditional Chinese medicine commonly used in clinical practice, typically to treat neurological diseases such as neurasthenia and traumatic brain injury. It may have positive effects on cerebral ischemia‒reperfusion injury (cI/R). This study aimed to assess the effects of GPW in a mouse model of cI/R and find its possible targets. C57BL/6J mice were used to establish the cI/R model, and the laser speckle doppler was used to determine the success of the model. GPW was administered intragastrically for 7 days, brain tissue sections were stained with TTC, HE, and TUNEL, Western blot assay was performed to detect the effect of apoptosis-related proteins. Furthermore, we screened active ingredients from the TCM Database and constructed a compound‒target network using the C"],"journal":["Frontiers in pharmacology"],"pagination":["1346226"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10955136"],"repository":["biostudies-literature"],"pubmed_title":["Pharmacological effects and target analysis of Guipi wan in the treatment of cerebral ischemia-reperfusion injury."],"pmcid":["PMC10955136"],"pubmed_authors":["Li X","Zhang J","Guo Y","Jiang W","Luo L","Liu A","Liu Q","Zhang M","Yu J"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacological effects and target analysis of Guipi wan in the treatment of cerebral ischemia-reperfusion injury.","description":"Guipi wan (GPW) is a traditional Chinese medicine commonly used in clinical practice, typically to treat neurological diseases such as neurasthenia and traumatic brain injury. It may have positive effects on cerebral ischemia‒reperfusion injury (cI/R). This study aimed to assess the effects of GPW in a mouse model of cI/R and find its possible targets. C57BL/6J mice were used to establish the cI/R model, and the laser speckle doppler was used to determine the success of the model. GPW was administered intragastrically for 7 days, brain tissue sections were stained with TTC, HE, and TUNEL, Western blot assay was performed to detect the effect of apoptosis-related proteins. Furthermore, we screened active ingredients from the TCM Database and constructed a compound‒target network using the C","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-22T13:00:43.27Z","creation":"2025-04-06T00:26:33.788Z"},"accession":"S-EPMC10955136","cross_references":{"pubmed":["38515838"],"doi":["10.3389/fphar.2024.1346226"]}}