{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["96(11)"],"submitter":["Eselem Bungu PS"],"pubmed_abstract":["A new and robust high-performance liquid chromatography (HPLC) method that separates poly(lactic acid) (PLA) according to its stereochemical composition is presented. Using this method, poly(l-lactide) incorporating trace amounts of <i>meso</i>-lactide resulting from the racemization is separated from the pristine polymer. To prove this aspect in more detail, a representative poly(l-lactic acid) standard, assumed to be highly homogeneous, was separated using this method. The result showed that this was not the case as a fraction incorporating <i>meso</i>-lactide due to racemization occurring during the synthesis is separated. Employing two-dimensional liquid chromatography (2D-LC), the molar mass differences of the separated species were investigated, and fractions with similar molecular s"],"journal":["Analytical chemistry"],"pagination":["4716-4725"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10955512"],"repository":["biostudies-literature"],"pubmed_title":["Stereochemical Heterogeneity Analysis of Polylactides by Multidimensional Liquid Chromatography."],"pmcid":["PMC10955512"],"pubmed_authors":["Pasch H","Luetzow K","Lettau O","Schulz M","Neffe AT","Eselem Bungu PS"],"additional_accession":[]},"is_claimable":false,"name":"Stereochemical Heterogeneity Analysis of Polylactides by Multidimensional Liquid Chromatography.","description":"A new and robust high-performance liquid chromatography (HPLC) method that separates poly(lactic acid) (PLA) according to its stereochemical composition is presented. Using this method, poly(l-lactide) incorporating trace amounts of <i>meso</i>-lactide resulting from the racemization is separated from the pristine polymer. To prove this aspect in more detail, a representative poly(l-lactic acid) standard, assumed to be highly homogeneous, was separated using this method. The result showed that this was not the case as a fraction incorporating <i>meso</i>-lactide due to racemization occurring during the synthesis is separated. Employing two-dimensional liquid chromatography (2D-LC), the molar mass differences of the separated species were investigated, and fractions with similar molecular s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-14T23:52:07.534Z","creation":"2025-04-06T00:27:36.594Z"},"accession":"S-EPMC10955512","cross_references":{"pubmed":["38465448"],"doi":["10.1021/acs.analchem.4c00336"]}}