{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yin R"],"funding":["NCRR NIH HHS","Office of Research Infrastructure Programs, National Institutes of Health","National Cancer Institute","NCI NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e202303331"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10957303"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(16)"],"pubmed_abstract":["Near-infrared (NIR) dyes are desirable for biological imaging applications including photoacoustic (PA) and fluorescence imaging. Nonetheless, current NIR dyes are often plagued by relatively large molecular weights, poor water solubility, and limited photostability. Herein, we provide the first examples of azaphosphinate dyes which display desirable properties such as low molecular weight, absorption/emission above 750 nm, and remarkable water solubility. In PA imaging, an azaphosphinate dye exhibited a 4.1-fold enhancement in intensity compared to commonly used standards, the ability to multiplex with existing dyes in whole blood, imaging depths of 2.75 cm in a tissue model, and contrast in mice. An improved derivative for fluorescence imaging displayed a >10-fold reduction in photobleaching in water compared to the FDA-approved indocyanine green dye and could be visualized in mice. This new dye class provides a robust scaffold for the development of photoacoustic or NIR fluorescence imaging agents."],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Azaphosphinate Dyes: A Low Molecular Weight Near-Infrared Scaffold for Development of Photoacoustic or Fluorescence Imaging Probes."],"pmcid":["PMC10957303"],"funding_grant_id":["S10RR025616","UM1CA186644","P30CA16059","R01 CA223767","R35GM148221","S10 RR025616","R01CA223767","P30CA044579","UM1 CA186644","R35 GM148221","P30 CA016059","P30 CA044579"],"pubmed_authors":["Fang Y","Grant S","He Y","He J","Yin R","Sykes JS","Stains CI","Brondsted F","Li L","McAfee JL"],"additional_accession":[]},"is_claimable":false,"name":"Azaphosphinate Dyes: A Low Molecular Weight Near-Infrared Scaffold for Development of Photoacoustic or Fluorescence Imaging Probes.","description":"Near-infrared (NIR) dyes are desirable for biological imaging applications including photoacoustic (PA) and fluorescence imaging. Nonetheless, current NIR dyes are often plagued by relatively large molecular weights, poor water solubility, and limited photostability. Herein, we provide the first examples of azaphosphinate dyes which display desirable properties such as low molecular weight, absorption/emission above 750 nm, and remarkable water solubility. In PA imaging, an azaphosphinate dye exhibited a 4.1-fold enhancement in intensity compared to commonly used standards, the ability to multiplex with existing dyes in whole blood, imaging depths of 2.75 cm in a tissue model, and contrast in mice. An improved derivative for fluorescence imaging displayed a >10-fold reduction in photobleaching in water compared to the FDA-approved indocyanine green dye and could be visualized in mice. This new dye class provides a robust scaffold for the development of photoacoustic or NIR fluorescence imaging agents.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T01:29:05.536Z","creation":"2025-04-04T01:29:05.536Z"},"accession":"S-EPMC10957303","cross_references":{"pubmed":["38206848"],"doi":["10.1002/chem.202303331"]}}