{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li JP"],"funding":["National Key Research and Development Plan","Scientific Research Fund of Zhejiang Provincial Education Department","National Natural Science Foundation of China","Medical Scientific Research Foundation of Zhejiang Province"],"pagination":["757-765"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10957810"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(3)"],"pubmed_abstract":["<h4>Purpose</h4>To investigate the prevalence of Y chromosome polymorphisms in Chinese men and analyze their associations with male infertility and female adverse pregnancy outcomes.<h4>Methods</h4>The clinical data of 32,055 Chinese men who underwent karyotype analysis from October 2014 to September 2019 were collected. Fisher's exact test, chi-square test, or Kruskal-Wallis test was used to analyze the effects of Y chromosome polymorphism on semen parameters, azoospermia factor (AZF) microdeletions, and female adverse pregnancy outcomes.<h4>Results</h4>The incidence of Y chromosome polymorphic variants was 1.19% (381/32,055) in Chinese men. The incidence of non-obstructive azoospermia (NOA) was significantly higher in men with the Yqh- variant than that in men with normal karyotype and o"],"journal":["Journal of assisted reproduction and genetics"],"pubmed_title":["Y chromosome polymorphisms contribute to an increased risk of non-obstructive azoospermia: a retrospective study of 32,055 Chinese men."],"pmcid":["PMC10957810"],"funding_grant_id":["Y202249537","82171596","2021KY190","2018YFC1002702"],"pubmed_authors":["Wu JG","Jin F","Zhang FB","Li JP","Liang ZY","Tian YH","Chen C","Chen WK","Li LJ"],"additional_accession":[]},"is_claimable":false,"name":"Y chromosome polymorphisms contribute to an increased risk of non-obstructive azoospermia: a retrospective study of 32,055 Chinese men.","description":"<h4>Purpose</h4>To investigate the prevalence of Y chromosome polymorphisms in Chinese men and analyze their associations with male infertility and female adverse pregnancy outcomes.<h4>Methods</h4>The clinical data of 32,055 Chinese men who underwent karyotype analysis from October 2014 to September 2019 were collected. Fisher's exact test, chi-square test, or Kruskal-Wallis test was used to analyze the effects of Y chromosome polymorphism on semen parameters, azoospermia factor (AZF) microdeletions, and female adverse pregnancy outcomes.<h4>Results</h4>The incidence of Y chromosome polymorphic variants was 1.19% (381/32,055) in Chinese men. The incidence of non-obstructive azoospermia (NOA) was significantly higher in men with the Yqh- variant than that in men with normal karyotype and o","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-03T23:36:49.768Z","creation":"2025-04-03T23:36:49.768Z"},"accession":"S-EPMC10957810","cross_references":{"pubmed":["38270748"],"doi":["10.1007/s10815-024-03022-y"]}}