biostudies-literatureLi JPNational Key Research and Development PlanScientific Research Fund of Zhejiang Provincial Education DepartmentNational Natural Science Foundation of ChinaMedical Scientific Research Foundation of Zhejiang Province757-765https://www.ebi.ac.uk/biostudies/studies/S-EPMC10957810biostudies-literatureUnknown41(3)<h4>Purpose</h4>To investigate the prevalence of Y chromosome polymorphisms in Chinese men and analyze their associations with male infertility and female adverse pregnancy outcomes.<h4>Methods</h4>The clinical data of 32,055 Chinese men who underwent karyotype analysis from October 2014 to September 2019 were collected. Fisher's exact test, chi-square test, or Kruskal-Wallis test was used to analyze the effects of Y chromosome polymorphism on semen parameters, azoospermia factor (AZF) microdeletions, and female adverse pregnancy outcomes.<h4>Results</h4>The incidence of Y chromosome polymorphic variants was 1.19% (381/32,055) in Chinese men. The incidence of non-obstructive azoospermia (NOA) was significantly higher in men with the Yqh- variant than that in men with normal karyotype and oJournal of assisted reproduction and geneticsY chromosome polymorphisms contribute to an increased risk of non-obstructive azoospermia: a retrospective study of 32,055 Chinese men.PMC10957810Y202249537821715962021KY1902018YFC1002702Wu JGJin FZhang FBLi JPLiang ZYTian YHChen CChen WKLi LJfalseY chromosome polymorphisms contribute to an increased risk of non-obstructive azoospermia: a retrospective study of 32,055 Chinese men.<h4>Purpose</h4>To investigate the prevalence of Y chromosome polymorphisms in Chinese men and analyze their associations with male infertility and female adverse pregnancy outcomes.<h4>Methods</h4>The clinical data of 32,055 Chinese men who underwent karyotype analysis from October 2014 to September 2019 were collected. Fisher's exact test, chi-square test, or Kruskal-Wallis test was used to analyze the effects of Y chromosome polymorphism on semen parameters, azoospermia factor (AZF) microdeletions, and female adverse pregnancy outcomes.<h4>Results</h4>The incidence of Y chromosome polymorphic variants was 1.19% (381/32,055) in Chinese men. The incidence of non-obstructive azoospermia (NOA) was significantly higher in men with the Yqh- variant than that in men with normal karyotype and o2024-01-01T00:00:00Z2024 Mar2025-04-03T23:36:49.768Z2025-04-03T23:36:49.768ZS-EPMC109578103827074810.1007/s10815-024-03022-y