{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(3)"],"submitter":["Alkon-Meadows T"],"pubmed_abstract":["<h4>Purpose</h4>To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo transfer (SEET) differ among women of self-reported racial and ethnic backgrounds.<h4>Methods</h4>This retrospective cohort study included all infertile patients of different self-reported racial backgrounds who underwent In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) and an autologous single euploid embryo transfer (SEET) from December 2015 to December 2019 at a single private and academic assisted reproduction technology center. Primary outcome measures included ploidy rates among different racial groups. Secondary outcomes included clinical pregnancy, clinical pregnancy loss, and live birth rates.<h4>Results</h4>Five thousand five hundred sixty-two patients who underwent an IVF cycle with ICSI-PGT-A were included. A total of 24,491 blastocysts were analyzed. White participants had on average more euploid embryos and higher euploidy rates when compared to their counterparts (p ≤ 0.0001). However, after controlling for confounding factors, there was no association between race and the odds of having  a higher euploidy rate (aOR 1.31; 95% CI 0.63-2.17, p = 0.42). A total of 4949 patients underwent SEET. Pregnancy outcomes did not differ among patients of varying self-reported races.<h4>Conclusions</h4>Euploidy rates and pregnancy outcomes were comparable among patients of different racial backgrounds who underwent a SEET."],"journal":["Journal of assisted reproduction and genetics"],"pagination":["693-702"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10957844"],"repository":["biostudies-literature"],"pubmed_title":["Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles."],"pmcid":["PMC10957844"],"pubmed_authors":["Copperman A","Buyuk E","Cacchione TA","Alkon-Meadows T","Hernandez-Nieto C","Gounko D","Lee J","Luna-Rojas M","Jackson-Bey T"],"additional_accession":[]},"is_claimable":false,"name":"Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles.","description":"<h4>Purpose</h4>To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo transfer (SEET) differ among women of self-reported racial and ethnic backgrounds.<h4>Methods</h4>This retrospective cohort study included all infertile patients of different self-reported racial backgrounds who underwent In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) and an autologous single euploid embryo transfer (SEET) from December 2015 to December 2019 at a single private and academic assisted reproduction technology center. Primary outcome measures included ploidy rates among different racial groups. Secondary outcomes included clinical pregnancy, clinical pregnancy loss, and live birth rates.<h4>Results</h4>Five thousand five hundred sixty-two patients who underwent an IVF cycle with ICSI-PGT-A were included. A total of 24,491 blastocysts were analyzed. White participants had on average more euploid embryos and higher euploidy rates when compared to their counterparts (p ≤ 0.0001). However, after controlling for confounding factors, there was no association between race and the odds of having  a higher euploidy rate (aOR 1.31; 95% CI 0.63-2.17, p = 0.42). A total of 4949 patients underwent SEET. Pregnancy outcomes did not differ among patients of varying self-reported races.<h4>Conclusions</h4>Euploidy rates and pregnancy outcomes were comparable among patients of different racial backgrounds who underwent a SEET.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T01:12:10.097Z","creation":"2025-04-04T01:12:10.097Z"},"accession":"S-EPMC10957844","cross_references":{"pubmed":["38294622"],"doi":["10.1007/s10815-024-03039-3"]}}