{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Tang Y"],"funding":["The Singapore National Research Foundation"],"pubmed_abstract":["Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PSs) through rational PS skeleton design and precise side-chain engineering to generate •O<sub>2</sub><sup>-</sup> and •OH under oxygen-free conditions using ultralow-power 808 nm photoexcitation for tumor-specific photodynamic ablation. The designed organic PS skeletons can generate electron-hole pairs to sensitize H<sub>2</sub>O into •O<sub>2</sub><sup>-</sup> and •OH under oxygen-free conditions with 808 nm photoexcitation, achieving NIR-photoexcited and oxygen-independent •O<sub>2</sub><sup>-</sup> and •OH production. Further, compared with commonly used alkyl side chains, glycol ol"],"journal":["Nature communications"],"pagination":["2530"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10957938"],"repository":["biostudies-literature"],"pubmed_title":["Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy."],"pmcid":["PMC10957938"],"pubmed_authors":["Tian J","Li Y","Huang W","Qi G","Liu B","Li B","Fan Q","Song W","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy.","description":"Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PSs) through rational PS skeleton design and precise side-chain engineering to generate •O<sub>2</sub><sup>-</sup> and •OH under oxygen-free conditions using ultralow-power 808 nm photoexcitation for tumor-specific photodynamic ablation. The designed organic PS skeletons can generate electron-hole pairs to sensitize H<sub>2</sub>O into •O<sub>2</sub><sup>-</sup> and •OH under oxygen-free conditions with 808 nm photoexcitation, achieving NIR-photoexcited and oxygen-independent •O<sub>2</sub><sup>-</sup> and •OH production. Further, compared with commonly used alkyl side chains, glycol ol","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-22T12:56:59.033Z","creation":"2025-04-06T00:29:34.531Z"},"accession":"S-EPMC10957938","cross_references":{"pubmed":["38514624"],"doi":["10.1038/s41467-024-46768-w"]}}