{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["142(5)"],"submitter":["Writing Committee for the Pediatric Eye Disease Investigator Group"],"pubmed_abstract":["<h4>Importance</h4>Increased myopic shift was found to be associated with 1 year of overminus spectacle treatment for children with intermittent exotropia (IXT). Persistence of myopic shift after discontinuing overminus spectacles is unknown.<h4>Objective</h4>To compare refractive error change over 3 years in children with IXT originally treated with overminus vs nonoverminus spectacles.<h4>Design, setting, and participants</h4>This study was an 18-month extension of the Trial of Overminus Spectacle Therapy for Intermittent Exotropia cohort, which previously randomized children aged 3 to 10 years with IXT and baseline spherical equivalent refractive error (SER) between -6.00 diopters (D) and 1.00 D to overminus spectacles (-2.50 D for 12 months, -1.25 D for 3 months, and nonoverminus for 3"],"journal":["JAMA ophthalmology"],"pagination":["417-428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10958385"],"repository":["biostudies-literature"],"pubmed_title":["Refractive Error Change and Overminus Lens Therapy for Childhood Intermittent Exotropia."],"pmcid":["PMC10958385"],"pubmed_authors":["Klaehn LD","Conner CL","Bohra L","Merrill KS","Sanders EN","Wall PB","Feis AE","Fergus LM","Kraus CL","Jensen AA","Romany G","Astle WF","Frazier M","Christoff A","Haider KM","Yamada T","Schulman-Ellis EL","Hopkins KB","Christiansen SP","Amster DM","Curtis LT","Poff SW","Shah BK","Writing Committee for the Pediatric Eye Disease Investigator Group","Hoepner JE","Bothun ED","Hahn AC","Jastrzemsbki BG","Twardowski CM","Taub MB","Toole AJ","Ecerova Z","Hatch SW","Bhatt AR","Meyers SR","Koutnik CA","Tzanetakos V","Olvera MN","Smith RM","Cupit SL","Jordan CO","Oechslin TS","Hatt SR","Paysse EA","Dean TW","Manny RE","Clausius DA","Petersen DB","Cobb P","Henderson RJ","Lyons AF","Raghuram A","Enyedi LB","Chung I","Lorenzana I","Nash DL","Connolly KS","Gunton KB","Parker SM","Austin DS","Repka MX","London R","Bailey MK","Cutrer BM","de Alba Campomanes AG","Walker KR","Cotter SA","Baker JD","LaMattina KC","Manuchian S","Good WV","Suh DW","Morrell BA","Peters RJ","Conley JA","Holtorf HL","Bitner DP","Colon BJ","Birch EE","Hoover DL","Davis B","Fang CC","Christian ML","Stewart ML","Retnasothie DV","Rutner D","Manh VM","Hilbrands J","Kraker RT","Cheung NL","Crossnoe CJ","Anderson HA","Bland TA","Li Z","Fouzdar Jain S","Leske DA","Rahmani B","Robinson JL","Fimbel BP","Forde RA","Marozas L","Roberts TL","Ralay Ranaivo H","Collins MLZ","Higgins RD","Holmes JM","Stevens JL","May LM","Castle KM","Liu X","Melia BM","Fishman DR","Waters AL","Koontz ER","Miller CC","Morrison KB","Yen KG","Bond LL","Wright MM","Silver JL","Donahue SP","Lim ME","Beaulieu WT","Miller AM","Chen AM","Tamkins SM","McMurtrey JR","Patel RA","Ventura GG","Sala A","Law CL","Slinger KE","Pediatric Eye Disease Investigator Group","Toro DO","Wolinski ET","Cooper K","Pineles SL","Boente CS","Mets-Halgrimson RB","Gafford JB","Varney KD","Myung J","Oseguera T","Argoubi A","Jhajj JK","McDowell PS","Pollack KE","Tychsen L","Evans PL","Roe MK","Beck RW","Droste PJ","Superstein R","Hercinovic A","Siatkowski RM","Dinani Z","Phillips PH","Morrison AM","Chamberlain C","Everett DF","Kramer AM","Stutz KM","Lazar EL","Ortiz G","Willen CM","Kulp MT","Franklin JM","Han S","Jackson JL","Pang Y","Sayani A","Eltzroth JM","Holleschau AM","Yonkers AM","Quebbemann MN","Ruark ST","Jones SK","Kong L","Titelbaum JR","Lee KA","Marsh JD","Thibeault M","Verderber LC","Brafford RC","Lambert JE","Schweinler BR","Jenewein EC","Allen M","Wernimont SM","Donahue Q","Leach S","Stec M","Erickson JW","Stevens NE","Ticho BH","Dillon AC","Alluri S","James YR","Wallace DK","Kurup SP","Bodack MI","Huang K","Plaumann MD","Woodard VC","Wang J","Gianfermi E","Haley WJ","Strul S","Erzurum SA","Summers AI","Plum LW","Weise KK","Wu R","Heyman CL","Tung IT","Shah VS","Shelton ER","Gray ME","Nylin E","Rogers DL","Martinson SR","Solis CS","Sutherland DR","De Leon EA","Lambert SR","Flanagan MA","Berns F","Qayum JN","Freedman SF","Esposito CA","Lyon DW","McCoy Vrablec L","Loud RN","Hahn-Parrott L","Peragallo JH","Diener-West MI","Geddie BE","Mohney BG","Cioffi KR","Meil GC","Montejo J","Tolbert TT","Kaplon JD","Hutchinson AK","Boyle NM","Morrison DG","Saunders RA","Perzyk SN","Grigorian AP","Scheiman MM","Alexander ML","Vricella M","Gertsch KR","Chandler DL","Crouch ER","Khan S","Krueger SL","Morgan L"],"additional_accession":[]},"is_claimable":false,"name":"Refractive Error Change and Overminus Lens Therapy for Childhood Intermittent Exotropia.","description":"<h4>Importance</h4>Increased myopic shift was found to be associated with 1 year of overminus spectacle treatment for children with intermittent exotropia (IXT). Persistence of myopic shift after discontinuing overminus spectacles is unknown.<h4>Objective</h4>To compare refractive error change over 3 years in children with IXT originally treated with overminus vs nonoverminus spectacles.<h4>Design, setting, and participants</h4>This study was an 18-month extension of the Trial of Overminus Spectacle Therapy for Intermittent Exotropia cohort, which previously randomized children aged 3 to 10 years with IXT and baseline spherical equivalent refractive error (SER) between -6.00 diopters (D) and 1.00 D to overminus spectacles (-2.50 D for 12 months, -1.25 D for 3 months, and nonoverminus for 3","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-08T19:50:56.124Z","creation":"2025-04-04T00:08:52.749Z"},"accession":"S-EPMC10958385","cross_references":{"pubmed":["38536764"],"doi":["10.1001/jamaophthalmol.2024.0276"]}}