biostudies-literatureUnknown142(5)Writing Committee for the Pediatric Eye Disease Investigator Group<h4>Importance</h4>Increased myopic shift was found to be associated with 1 year of overminus spectacle treatment for children with intermittent exotropia (IXT). Persistence of myopic shift after discontinuing overminus spectacles is unknown.<h4>Objective</h4>To compare refractive error change over 3 years in children with IXT originally treated with overminus vs nonoverminus spectacles.<h4>Design, setting, and participants</h4>This study was an 18-month extension of the Trial of Overminus Spectacle Therapy for Intermittent Exotropia cohort, which previously randomized children aged 3 to 10 years with IXT and baseline spherical equivalent refractive error (SER) between -6.00 diopters (D) and 1.00 D to overminus spectacles (-2.50 D for 12 months, -1.25 D for 3 months, and nonoverminus for 3JAMA ophthalmology417-428https://www.ebi.ac.uk/biostudies/studies/S-EPMC10958385biostudies-literatureRefractive Error Change and Overminus Lens Therapy for Childhood Intermittent Exotropia.PMC10958385Klaehn LDConner CLBohra LMerrill KSSanders ENWall PBFeis AEFergus LMKraus CLJensen AARomany GAstle WFFrazier MChristoff AHaider KMYamada TSchulman-Ellis ELHopkins KBChristiansen SPAmster DMCurtis LTPoff SWShah BKWriting Committee for the Pediatric Eye Disease Investigator GroupHoepner JEBothun EDHahn ACJastrzemsbki BGTwardowski CMTaub MBToole AJEcerova ZHatch SWBhatt ARMeyers SRKoutnik CATzanetakos VOlvera MNSmith RMCupit SLJordan COOechslin TSHatt SRPaysse EADean TWManny REClausius DAPetersen DBCobb PHenderson RJLyons AFRaghuram AEnyedi LBChung ILorenzana INash DLConnolly KSGunton KBParker SMAustin DSRepka MXLondon RBailey MKCutrer BMde Alba Campomanes AGWalker KRCotter SABaker JDLaMattina KCManuchian SGood WVSuh DWMorrell BAPeters RJConley JAHoltorf HLBitner DPColon BJBirch EEHoover DLDavis BFang CCChristian MLStewart MLRetnasothie DVRutner DManh VMHilbrands JKraker RTCheung NLCrossnoe CJAnderson HABland TALi ZFouzdar Jain SLeske DARahmani BRobinson JLFimbel BPForde RAMarozas LRoberts TLRalay Ranaivo HCollins MLZHiggins RDHolmes JMStevens JLMay LMCastle KMLiu XMelia BMFishman DRWaters ALKoontz ERMiller CCMorrison KBYen KGBond LLWright MMSilver JLDonahue SPLim MEBeaulieu WTMiller AMChen AMTamkins SMMcMurtrey JRPatel RAVentura GGSala ALaw CLSlinger KEPediatric Eye Disease Investigator GroupToro DOWolinski ETCooper KPineles SLBoente CSMets-Halgrimson RBGafford JBVarney KDMyung JOseguera TArgoubi AJhajj JKMcDowell PSPollack KETychsen LEvans PLRoe MKBeck RWDroste PJSuperstein RHercinovic ASiatkowski RMDinani ZPhillips PHMorrison AMChamberlain CEverett DFKramer AMStutz KMLazar ELOrtiz GWillen CMKulp MTFranklin JMHan SJackson JLPang YSayani AEltzroth JMHolleschau AMYonkers AMQuebbemann MNRuark STJones SKKong LTitelbaum JRLee KAMarsh JDThibeault MVerderber LCBrafford RCLambert JESchweinler BRJenewein ECAllen MWernimont SMDonahue QLeach SStec MErickson JWStevens NETicho BHDillon ACAlluri SJames YRWallace DKKurup SPBodack MIHuang KPlaumann MDWoodard VCWang JGianfermi EHaley WJStrul SErzurum SASummers AIPlum LWWeise KKWu RHeyman CLTung ITShah VSShelton ERGray MENylin ERogers DLMartinson SRSolis CSSutherland DRDe Leon EALambert SRFlanagan MABerns FQayum JNFreedman SFEsposito CALyon DWMcCoy Vrablec LLoud RNHahn-Parrott LPeragallo JHDiener-West MIGeddie BEMohney BGCioffi KRMeil GCMontejo JTolbert TTKaplon JDHutchinson AKBoyle NMMorrison DGSaunders RAPerzyk SNGrigorian APScheiman MMAlexander MLVricella MGertsch KRChandler DLCrouch ERKhan SKrueger SLMorgan LfalseRefractive Error Change and Overminus Lens Therapy for Childhood Intermittent Exotropia.<h4>Importance</h4>Increased myopic shift was found to be associated with 1 year of overminus spectacle treatment for children with intermittent exotropia (IXT). Persistence of myopic shift after discontinuing overminus spectacles is unknown.<h4>Objective</h4>To compare refractive error change over 3 years in children with IXT originally treated with overminus vs nonoverminus spectacles.<h4>Design, setting, and participants</h4>This study was an 18-month extension of the Trial of Overminus Spectacle Therapy for Intermittent Exotropia cohort, which previously randomized children aged 3 to 10 years with IXT and baseline spherical equivalent refractive error (SER) between -6.00 diopters (D) and 1.00 D to overminus spectacles (-2.50 D for 12 months, -1.25 D for 3 months, and nonoverminus for 32024-01-01T00:00:00Z2024 May2026-04-08T19:50:56.124Z2025-04-04T00:08:52.749ZS-EPMC109583853853676410.1001/jamaophthalmol.2024.0276