{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(12)"],"submitter":["Uguz I"],"pubmed_abstract":["The ability to amplify, translate, and process small ionic potential fluctuations of neural processes directly at the recording site is essential to improve the performance of neural implants. Organic front-end analog electronics are ideal for this application, allowing for minimally invasive amplifiers owing to their tissue-like mechanical properties. Here, we demonstrate fully organic complementary circuits by pairing depletion- and enhancement-mode p- and n-type organic electrochemical transistors (OECTs). With precise geometry tuning and a vertical device architecture, we achieve overlapping output characteristics and integrate them into amplifiers with single neuronal dimensions (20 micrometers). Amplifiers with combined p- and n-OECTs result in voltage-to-voltage amplification with a gain of >30 decibels. We also leverage depletion and enhancement-mode p-OECTs with matching characteristics to demonstrate a differential recording capability with high common mode rejection rate (>60 decibels). Integrating OECT-based front-end amplifiers into a flexible shank form factor enables single-neuron recording in the mouse cortex with on-site filtering and amplification."],"journal":["Science advances"],"pagination":["eadi9710"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10959418"],"repository":["biostudies-literature"],"pubmed_title":["Complementary integration of organic electrochemical transistors for front-end amplifier circuits of flexible neural implants."],"pmcid":["PMC10959418"],"pubmed_authors":["Sheelamanthula R","Fabbri JD","Shepard KL","Griggs S","Ohayon D","Yilmaz S","Uguz I","Inal S","McCulloch I"],"additional_accession":[]},"is_claimable":false,"name":"Complementary integration of organic electrochemical transistors for front-end amplifier circuits of flexible neural implants.","description":"The ability to amplify, translate, and process small ionic potential fluctuations of neural processes directly at the recording site is essential to improve the performance of neural implants. Organic front-end analog electronics are ideal for this application, allowing for minimally invasive amplifiers owing to their tissue-like mechanical properties. Here, we demonstrate fully organic complementary circuits by pairing depletion- and enhancement-mode p- and n-type organic electrochemical transistors (OECTs). With precise geometry tuning and a vertical device architecture, we achieve overlapping output characteristics and integrate them into amplifiers with single neuronal dimensions (20 micrometers). Amplifiers with combined p- and n-OECTs result in voltage-to-voltage amplification with a gain of >30 decibels. We also leverage depletion and enhancement-mode p-OECTs with matching characteristics to demonstrate a differential recording capability with high common mode rejection rate (>60 decibels). Integrating OECT-based front-end amplifiers into a flexible shank form factor enables single-neuron recording in the mouse cortex with on-site filtering and amplification.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T20:07:12.32Z","creation":"2025-04-04T20:07:12.32Z"},"accession":"S-EPMC10959418","cross_references":{"pubmed":["38517957"],"doi":["10.1126/sciadv.adi9710"]}}